Cargando…

Structural insights into Ras regulation by SIN1

Over the years it has been established that SIN1, a key component of mTORC2, could interact with Ras family small GTPases through its Ras-binding domain (RBD). The physical association of Ras and SIN1/mTORC2 could potentially affect both mTORC2 and Ras-ERK pathways. To decipher the precise molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Yuyuan, Ding, Lei, Meng, Xianhui, Potter, Meg, Kearney, Alison L., Zhang, Jie, Sun, Jie, James, David E., Yang, Guang, Zhou, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171633/ https://www.ncbi.nlm.nih.gov/pubmed/35522713 http://dx.doi.org/10.1073/pnas.2119990119

Ejemplares similares

New mechanistic insights into the RAS-SIN1 interaction at the membrane
por: Pudewell, Silke, et al.
Publicado: (2022)

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
por: Cruz-Migoni, Abimael, et al.
Publicado: (2019)

A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane
por: Lin, Chun-Wei, et al.
Publicado: (2022)

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket
por: Wallon, Lauren, et al.
Publicado: (2022)

Convergence of Ras- and Rac-regulated formin pathways is pivotal for phagosome formation and particle uptake in Dictyostelium
por: Körber, Sarah, et al.
Publicado: (2023)

Structural insights into galanin receptor signaling
por: Jiang, Wentong, et al.
Publicado: (2022)

Structural insights into translation regulation by the THF-II riboswitch
por: Xu, Lilei, et al.
Publicado: (2023)

Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria
por: Shi, Jing, et al.
Publicado: (2023)

Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities
por: Herman, Jacob A., et al.
Publicado: (2022)

Structural and functional insights into the chloroplast division site regulators PARC6 and PDV1 in the intermembrane space
por: Sun, Qingqing, et al.
Publicado: (2023)

Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
por: Lai, Lick Pui, et al.
Publicado: (2022)

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
por: Iwig, Jeffrey S, et al.
Publicado: (2013)

High-resolution structural insights into the heliorhodopsin family
por: Kovalev, K., et al.
Publicado: (2020)

Structural basis for regulation of SOS response in bacteria
por: Gao, Bo, et al.
Publicado: (2023)

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins
por: Ingólfsson, Helgi I., et al.
Publicado: (2022)

Structural insights into α-synuclein monomer–fibril interactions
por: Kumari, Pratibha, et al.
Publicado: (2021)

Structural insights into sphingosine-1-phosphate receptor activation
por: Yu, Leiye, et al.
Publicado: (2022)

Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling
por: Lone, Mehraj-U-Din, et al.
Publicado: (2019)

ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation
por: Liu, Ximeng, et al.
Publicado: (2023)

Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly
por: Fang, Qianglin, et al.
Publicado: (2022)

Structural insights into unique features of the human mitochondrial ribosome recycling
por: Koripella, Ravi K., et al.
Publicado: (2019)

Structural insight and characterization of human Twinkle helicase in mitochondrial disease
por: Riccio, Amanda A., et al.
Publicado: (2022)

Structural insights into constitutive activity of 5-HT(6) receptor
por: He, Licong, et al.
Publicado: (2023)

Structural insights into the multifunctionality of rabies virus P3 protein
por: Sethi, Ashish, et al.
Publicado: (2023)

Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling
por: Cooper, Jason F., et al.
Publicado: (2021)

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke
por: Takahashi, Hiroo, et al.
Publicado: (2021)

Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding
por: Cheng, Meng-Ting, et al.
Publicado: (2022)

Al ras de lona... 3 caídas sin límite de enfoques
por: Arcos Robles, Anaid
Publicado: (2006)

Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
por: Zhang, Xiao, et al.
Publicado: (2019)

Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis
por: Soufari, Heddy, et al.
Publicado: (2020)

Structural and functional insight into mismatch extension by human DNA polymerase α
por: Baranovskiy, Andrey G., et al.
Publicado: (2022)

Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
por: Ilter, Metehan, et al.
Publicado: (2022)

SIN3A Regulates Porcine Early Embryonic Development by Modulating CCNB1 Expression
por: Luo, Lei, et al.
Publicado: (2021)

Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer
por: Cheng, Derek K., et al.
Publicado: (2021)

Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication
por: Zhang, Yue, et al.
Publicado: (2022)

Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures
por: Sun, Stella Y., et al.
Publicado: (2022)

Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex
por: Xie, Tian, et al.
Publicado: (2023)

The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo
por: Xiong, Cong, et al.
Publicado: (2015)

Myelin sheath structure and regeneration in peripheral nerve injury repair
por: Liu, Bin, et al.
Publicado: (2019)

Structural and functional insights into the unique CBS–CP12 fusion protein family in cyanobacteria
por: Hackenberg, Claudia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0864im1j0967se28ddva5ns0ns