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Distinct roles of the Na(+) binding sites in the allosteric coupling mechanism of the glutamate transporter homolog, Glt(Ph)
Glutamate transporters carry out the concentrative uptake of glutamate by harnessing the ionic gradients present across cellular membranes. A central step in the transport mechanism is the coupled binding of Na(+) and substrate. The sodium coupled Asp transporter, Glt(Ph) is an archaeal homolog of g...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171649/ https://www.ncbi.nlm.nih.gov/pubmed/35507872 http://dx.doi.org/10.1073/pnas.2121653119 |