An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

[Image: see text] Understanding the factors that underpin the enormous catalytic proficiencies of enzymes is fundamental to catalysis and enzyme design. Enzymes are, in part, able to achieve high catalytic proficiencies by utilizing the binding energy derived from nonreacting portions of the substra...

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Detalles Bibliográficos
Autores principales: Robertson, Angus J., Cruz-Navarrete, F. Aaron, Wood, Henry P., Vekaria, Nikita, Hounslow, Andrea M., Bisson, Claudine, Cliff, Matthew J., Baxter, Nicola J., Waltho, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171722/
https://www.ncbi.nlm.nih.gov/pubmed/35692864
http://dx.doi.org/10.1021/acscatal.1c05524

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