COVID-19 and Down syndrome: the spark in the fuel

In individuals with Down syndrome, immune dysregulation is partially caused by chromosome 21 trisomy. Here, we discuss how these immune differences may result in poorer COVID-19 outcomes, including diminished responses to vaccination and possibly elevated risk for long COVID.

Detalles Bibliográficos
Autores principales: Majithia, Manini, Ribeiro, Susan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171732/
https://www.ncbi.nlm.nih.gov/pubmed/35672483
http://dx.doi.org/10.1038/s41577-022-00745-w
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author Majithia, Manini
Ribeiro, Susan P.
author_facet Majithia, Manini
Ribeiro, Susan P.
author_sort Majithia, Manini
collection PubMed
description In individuals with Down syndrome, immune dysregulation is partially caused by chromosome 21 trisomy. Here, we discuss how these immune differences may result in poorer COVID-19 outcomes, including diminished responses to vaccination and possibly elevated risk for long COVID.
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spelling pubmed-91717322022-06-08 COVID-19 and Down syndrome: the spark in the fuel Majithia, Manini Ribeiro, Susan P. Nat Rev Immunol Comment In individuals with Down syndrome, immune dysregulation is partially caused by chromosome 21 trisomy. Here, we discuss how these immune differences may result in poorer COVID-19 outcomes, including diminished responses to vaccination and possibly elevated risk for long COVID. Nature Publishing Group UK 2022-06-07 2022 /pmc/articles/PMC9171732/ /pubmed/35672483 http://dx.doi.org/10.1038/s41577-022-00745-w Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Majithia, Manini
Ribeiro, Susan P.
COVID-19 and Down syndrome: the spark in the fuel
title COVID-19 and Down syndrome: the spark in the fuel
title_full COVID-19 and Down syndrome: the spark in the fuel
title_fullStr COVID-19 and Down syndrome: the spark in the fuel
title_full_unstemmed COVID-19 and Down syndrome: the spark in the fuel
title_short COVID-19 and Down syndrome: the spark in the fuel
title_sort covid-19 and down syndrome: the spark in the fuel
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171732/
https://www.ncbi.nlm.nih.gov/pubmed/35672483
http://dx.doi.org/10.1038/s41577-022-00745-w
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