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Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26

Age-related macular degeneration (AMD) is a leading cause of visual loss. It has a strong genetic basis, and common haplotypes on chromosome (Chr) 1 (CFH Y402H variant) and on Chr10 (near HTRA1/ARMS2) contribute the most risk. Little is known about the early molecular and cellular processes in AMD,...

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Detalles Bibliográficos
Autores principales:	Mcharg, Selina, Booth, Laura, Perveen, Rahat, Riba Garcia, Isabel, Brace, Nicole, Bayatti, Nadhim, Sergouniotis, Panagiotis I., Phillips, Alexander M., Day, Anthony J., Black, Graeme C. M., Clark, Simon J., Dowsey, Andrew W., Unwin, Richard D., Bishop, Paul N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171765/ https://www.ncbi.nlm.nih.gov/pubmed/35561216 http://dx.doi.org/10.1073/pnas.2118510119

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