Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24

Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective in treating type 2 diabetes and obesity with proven cardiovascular benefits. However, most of these agonists are peptides and require subcutaneous injection except for orally available semaglutide. Boc5 was identified as the first orth...

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Detalles Bibliográficos
Autores principales: Cong, Zhaotong, Zhou, Qingtong, Li, Yang, Chen, Li-Nan, Zhang, Zi-Chen, Liang, Anyi, Liu, Qing, Wu, Xiaoyan, Dai, Antao, Xia, Tian, Wu, Wei, Zhang, Yan, Yang, Dehua, Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171782/
https://www.ncbi.nlm.nih.gov/pubmed/35561211
http://dx.doi.org/10.1073/pnas.2200155119

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