HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain’s allostery and unfolding upon B12 and TonB binding

To import large metabolites across the outer membrane of gram-negative bacteria, TonB-dependent transporters (TBDTs) undergo significant conformational change. After substrate binding in BtuB, the Escherichia coli vitamin B12 TBDT, TonB binds and couples BtuB to the inner-membrane proton motive forc...

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Detalles Bibliográficos
Autores principales: Zmyslowski, Adam M., Baxa, Michael C., Gagnon, Isabelle A., Sosnick, Tobin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171809/
https://www.ncbi.nlm.nih.gov/pubmed/35549554
http://dx.doi.org/10.1073/pnas.2119436119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171809/
https://www.ncbi.nlm.nih.gov/pubmed/35549554
http://dx.doi.org/10.1073/pnas.2119436119

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