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The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)

Whereas younger female patients were diagnosed with idiopathic pulmonary arterial hypertension (IPAH) in 1980s, it is now frequently encountered in elderly patients with cardiovascular comorbidities (CVCs) associated with increased risk for left heart disease. We present data until November 2019 reg...

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Autores principales: Arvanitaki, Alexandra, Vrana, Elena, Boutsikou, Maria, Anthi, Anastasia, Apostolopoulou, Sotiria, Avgeropoulou, Aikaterini, Demerouti, Eftychia, Patrianakos, Alexandros, Karyofyllis, Panagiotis, Mitrouska, Ioanna, Mouratoglou, Sophia A., Naka, Katerina K., Orfanos, Stylianos E., Panagiotidou, Evangelia, Pitsiou, Georgia, Rammos, Spyridon, Stanopoulos, Ioannis, Thomaidi, Adina, Frogoudaki, Alexandra, Boutou, Afroditi, Anastasiadis, George, Brili, Styliani, Tsangaris, Iraklis, Tsiapras, Dimitrios, Voudris, Vassilios, Manginas, Athanasios, Giannakoulas, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171835/
https://www.ncbi.nlm.nih.gov/pubmed/35685948
http://dx.doi.org/10.1002/pul2.12086
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author Arvanitaki, Alexandra
Vrana, Elena
Boutsikou, Maria
Anthi, Anastasia
Apostolopoulou, Sotiria
Avgeropoulou, Aikaterini
Demerouti, Eftychia
Patrianakos, Alexandros
Karyofyllis, Panagiotis
Mitrouska, Ioanna
Mouratoglou, Sophia A.
Naka, Katerina K.
Orfanos, Stylianos E.
Panagiotidou, Evangelia
Pitsiou, Georgia
Rammos, Spyridon
Stanopoulos, Ioannis
Thomaidi, Adina
Frogoudaki, Alexandra
Boutou, Afroditi
Anastasiadis, George
Brili, Styliani
Tsangaris, Iraklis
Tsiapras, Dimitrios
Voudris, Vassilios
Manginas, Athanasios
Giannakoulas, George
author_facet Arvanitaki, Alexandra
Vrana, Elena
Boutsikou, Maria
Anthi, Anastasia
Apostolopoulou, Sotiria
Avgeropoulou, Aikaterini
Demerouti, Eftychia
Patrianakos, Alexandros
Karyofyllis, Panagiotis
Mitrouska, Ioanna
Mouratoglou, Sophia A.
Naka, Katerina K.
Orfanos, Stylianos E.
Panagiotidou, Evangelia
Pitsiou, Georgia
Rammos, Spyridon
Stanopoulos, Ioannis
Thomaidi, Adina
Frogoudaki, Alexandra
Boutou, Afroditi
Anastasiadis, George
Brili, Styliani
Tsangaris, Iraklis
Tsiapras, Dimitrios
Voudris, Vassilios
Manginas, Athanasios
Giannakoulas, George
author_sort Arvanitaki, Alexandra
collection PubMed
description Whereas younger female patients were diagnosed with idiopathic pulmonary arterial hypertension (IPAH) in 1980s, it is now frequently encountered in elderly patients with cardiovascular comorbidities (CVCs) associated with increased risk for left heart disease. We present data until November 2019 regarding specific features and clinical outcomes of IPAH population from the Hellenic Pulmonary Hypertension Registry (HOPE). Patients were divided into two groups based on the presence of ≥ or <3 CVCs, arterial hypertension, diabetes mellitus, obesity, presence of coronary artery disease, or atrial fibrillation. Overall, 77 patients with IPAH (55.1 [interquartile range, IQR: 24.1] years, 62.8% women) have been recorded. Fifteen patients (19.2%) had ≥3 CVCs, while 25 (32%) were over 65 years old. Patients with ≥3 CVCs were older, presented an almost equal female to male ratio, walked less in 6‐min walk test, and had lower mean arterial pulmonary pressure and pulmonary vascular resistance at baseline than patients with less CVCs. Fewer patients with ≥3 CVCs received PAH‐specific treatment compared to patients with less comorbidities (n = 11 [73.3%] versus n = 58 [95.5%], p = 0.02). During a median follow‐up period of 3.8 (IQR: 2.7) years, 18 patients died (all‐cause mortality 24.3%). Male sex and older age were independent predictors of mortality and/or lung transplantation, while CVCs did not have a significant impact on clinical outcomes. In this nationwide, register‐based study, the epidemiology of IPAH involves older patients with CVCs, who seem to have less hemodynamic compromise, but worse functional impairment and are treated less aggressively with PAH pharmacotherapy.
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spelling pubmed-91718352022-06-08 The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE) Arvanitaki, Alexandra Vrana, Elena Boutsikou, Maria Anthi, Anastasia Apostolopoulou, Sotiria Avgeropoulou, Aikaterini Demerouti, Eftychia Patrianakos, Alexandros Karyofyllis, Panagiotis Mitrouska, Ioanna Mouratoglou, Sophia A. Naka, Katerina K. Orfanos, Stylianos E. Panagiotidou, Evangelia Pitsiou, Georgia Rammos, Spyridon Stanopoulos, Ioannis Thomaidi, Adina Frogoudaki, Alexandra Boutou, Afroditi Anastasiadis, George Brili, Styliani Tsangaris, Iraklis Tsiapras, Dimitrios Voudris, Vassilios Manginas, Athanasios Giannakoulas, George Pulm Circ Research Articles Whereas younger female patients were diagnosed with idiopathic pulmonary arterial hypertension (IPAH) in 1980s, it is now frequently encountered in elderly patients with cardiovascular comorbidities (CVCs) associated with increased risk for left heart disease. We present data until November 2019 regarding specific features and clinical outcomes of IPAH population from the Hellenic Pulmonary Hypertension Registry (HOPE). Patients were divided into two groups based on the presence of ≥ or <3 CVCs, arterial hypertension, diabetes mellitus, obesity, presence of coronary artery disease, or atrial fibrillation. Overall, 77 patients with IPAH (55.1 [interquartile range, IQR: 24.1] years, 62.8% women) have been recorded. Fifteen patients (19.2%) had ≥3 CVCs, while 25 (32%) were over 65 years old. Patients with ≥3 CVCs were older, presented an almost equal female to male ratio, walked less in 6‐min walk test, and had lower mean arterial pulmonary pressure and pulmonary vascular resistance at baseline than patients with less CVCs. Fewer patients with ≥3 CVCs received PAH‐specific treatment compared to patients with less comorbidities (n = 11 [73.3%] versus n = 58 [95.5%], p = 0.02). During a median follow‐up period of 3.8 (IQR: 2.7) years, 18 patients died (all‐cause mortality 24.3%). Male sex and older age were independent predictors of mortality and/or lung transplantation, while CVCs did not have a significant impact on clinical outcomes. In this nationwide, register‐based study, the epidemiology of IPAH involves older patients with CVCs, who seem to have less hemodynamic compromise, but worse functional impairment and are treated less aggressively with PAH pharmacotherapy. John Wiley and Sons Inc. 2022-06-07 /pmc/articles/PMC9171835/ /pubmed/35685948 http://dx.doi.org/10.1002/pul2.12086 Text en © 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Arvanitaki, Alexandra
Vrana, Elena
Boutsikou, Maria
Anthi, Anastasia
Apostolopoulou, Sotiria
Avgeropoulou, Aikaterini
Demerouti, Eftychia
Patrianakos, Alexandros
Karyofyllis, Panagiotis
Mitrouska, Ioanna
Mouratoglou, Sophia A.
Naka, Katerina K.
Orfanos, Stylianos E.
Panagiotidou, Evangelia
Pitsiou, Georgia
Rammos, Spyridon
Stanopoulos, Ioannis
Thomaidi, Adina
Frogoudaki, Alexandra
Boutou, Afroditi
Anastasiadis, George
Brili, Styliani
Tsangaris, Iraklis
Tsiapras, Dimitrios
Voudris, Vassilios
Manginas, Athanasios
Giannakoulas, George
The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_full The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_fullStr The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_full_unstemmed The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_short The impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_sort impact of cardiovascular comorbidities associated with risk for left heart disease on idiopathic pulmonary arterial hypertension: data from the hellenic pulmonary hypertension registry (hope)
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171835/
https://www.ncbi.nlm.nih.gov/pubmed/35685948
http://dx.doi.org/10.1002/pul2.12086
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