The role of YAP1 in liver cancer stem cells: proven and potential mechanisms

YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research fi...

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Detalles Bibliográficos
Autores principales: Wu, Haofeng, Liu, Yachong, Liao, Zhibin, Mo, Jie, Zhang, Qiaofeng, Zhang, Bixiang, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171972/
https://www.ncbi.nlm.nih.gov/pubmed/35672802
http://dx.doi.org/10.1186/s40364-022-00387-z
Descripción
Sumario:YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely associated with YAP1-induced tumor initiation and progression. This article reviews the advancements made in research on the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that require further study.

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