The role of YAP1 in liver cancer stem cells: proven and potential mechanisms

YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research fi...

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Autores principales: Wu, Haofeng, Liu, Yachong, Liao, Zhibin, Mo, Jie, Zhang, Qiaofeng, Zhang, Bixiang, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171972/
https://www.ncbi.nlm.nih.gov/pubmed/35672802
http://dx.doi.org/10.1186/s40364-022-00387-z
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author Wu, Haofeng
Liu, Yachong
Liao, Zhibin
Mo, Jie
Zhang, Qiaofeng
Zhang, Bixiang
Zhang, Lei
author_facet Wu, Haofeng
Liu, Yachong
Liao, Zhibin
Mo, Jie
Zhang, Qiaofeng
Zhang, Bixiang
Zhang, Lei
author_sort Wu, Haofeng
collection PubMed
description YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely associated with YAP1-induced tumor initiation and progression. This article reviews the advancements made in research on the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that require further study.
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spelling pubmed-91719722022-06-08 The role of YAP1 in liver cancer stem cells: proven and potential mechanisms Wu, Haofeng Liu, Yachong Liao, Zhibin Mo, Jie Zhang, Qiaofeng Zhang, Bixiang Zhang, Lei Biomark Res Review YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely associated with YAP1-induced tumor initiation and progression. This article reviews the advancements made in research on the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that require further study. BioMed Central 2022-06-07 /pmc/articles/PMC9171972/ /pubmed/35672802 http://dx.doi.org/10.1186/s40364-022-00387-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, Haofeng
Liu, Yachong
Liao, Zhibin
Mo, Jie
Zhang, Qiaofeng
Zhang, Bixiang
Zhang, Lei
The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
title The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
title_full The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
title_fullStr The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
title_full_unstemmed The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
title_short The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
title_sort role of yap1 in liver cancer stem cells: proven and potential mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171972/
https://www.ncbi.nlm.nih.gov/pubmed/35672802
http://dx.doi.org/10.1186/s40364-022-00387-z
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