The current state of molecular profiling in gastrointestinal malignancies

This is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and what to expect from this evolving field in the future. Individualized medicine is moving from broad panel testing of numerous genes or gene products in tumor biopsy samples, identifying biomarkers of pr...

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Autores principales: Mukherji, Reetu, Yin, Chao, Hameed, Rumaisa, Alqahtani, Ali Z., Kulasekaran, Monika, He, Aiwu R., Weinberg, Benjamin A., Marshall, John L., Hartley, Marion L., Noel, Marcus S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172079/
https://www.ncbi.nlm.nih.gov/pubmed/35668531
http://dx.doi.org/10.1186/s13062-022-00322-0
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author Mukherji, Reetu
Yin, Chao
Hameed, Rumaisa
Alqahtani, Ali Z.
Kulasekaran, Monika
He, Aiwu R.
Weinberg, Benjamin A.
Marshall, John L.
Hartley, Marion L.
Noel, Marcus S.
author_facet Mukherji, Reetu
Yin, Chao
Hameed, Rumaisa
Alqahtani, Ali Z.
Kulasekaran, Monika
He, Aiwu R.
Weinberg, Benjamin A.
Marshall, John L.
Hartley, Marion L.
Noel, Marcus S.
author_sort Mukherji, Reetu
collection PubMed
description This is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and what to expect from this evolving field in the future. Individualized medicine is moving from broad panel testing of numerous genes or gene products in tumor biopsy samples, identifying biomarkers of prognosis and treatment response, to relatively noninvasive liquid biopsy assays, building on what we have learned in our tumor analysis and growing into its own evolving predictive and prognostic subspecialty. Hence, the field of GI precision oncology is exploding, and this review endeavors to summarize where we are now in preparation for the journey ahead.
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spelling pubmed-91720792022-06-08 The current state of molecular profiling in gastrointestinal malignancies Mukherji, Reetu Yin, Chao Hameed, Rumaisa Alqahtani, Ali Z. Kulasekaran, Monika He, Aiwu R. Weinberg, Benjamin A. Marshall, John L. Hartley, Marion L. Noel, Marcus S. Biol Direct Review This is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and what to expect from this evolving field in the future. Individualized medicine is moving from broad panel testing of numerous genes or gene products in tumor biopsy samples, identifying biomarkers of prognosis and treatment response, to relatively noninvasive liquid biopsy assays, building on what we have learned in our tumor analysis and growing into its own evolving predictive and prognostic subspecialty. Hence, the field of GI precision oncology is exploding, and this review endeavors to summarize where we are now in preparation for the journey ahead. BioMed Central 2022-06-06 /pmc/articles/PMC9172079/ /pubmed/35668531 http://dx.doi.org/10.1186/s13062-022-00322-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mukherji, Reetu
Yin, Chao
Hameed, Rumaisa
Alqahtani, Ali Z.
Kulasekaran, Monika
He, Aiwu R.
Weinberg, Benjamin A.
Marshall, John L.
Hartley, Marion L.
Noel, Marcus S.
The current state of molecular profiling in gastrointestinal malignancies
title The current state of molecular profiling in gastrointestinal malignancies
title_full The current state of molecular profiling in gastrointestinal malignancies
title_fullStr The current state of molecular profiling in gastrointestinal malignancies
title_full_unstemmed The current state of molecular profiling in gastrointestinal malignancies
title_short The current state of molecular profiling in gastrointestinal malignancies
title_sort current state of molecular profiling in gastrointestinal malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172079/
https://www.ncbi.nlm.nih.gov/pubmed/35668531
http://dx.doi.org/10.1186/s13062-022-00322-0
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