Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort

We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n =...

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Autores principales: Boeddha, Navin P., Schlapbach, Luregn J., Visser, Idse H., Jansen, Nicolaas J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172174/
https://www.ncbi.nlm.nih.gov/pubmed/35672773
http://dx.doi.org/10.1186/s40560-022-00618-3
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author Boeddha, Navin P.
Schlapbach, Luregn J.
Visser, Idse H.
Jansen, Nicolaas J. G.
author_facet Boeddha, Navin P.
Schlapbach, Luregn J.
Visser, Idse H.
Jansen, Nicolaas J. G.
author_sort Boeddha, Navin P.
collection PubMed
description We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n = 4096; AUC 0.70 (95% CI 0.67–0.73)) and in children with sepsis (n = 1690; AUC 0.71 (0.67–0.76)). aPSS can be an adequate tool to predict outcome in children admitted to PICU with invasive infection or sepsis, especially in situations where lactate is not available within 60 min.
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spelling pubmed-91721742022-06-08 Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort Boeddha, Navin P. Schlapbach, Luregn J. Visser, Idse H. Jansen, Nicolaas J. G. J Intensive Care Letter to the Editor We validated an adapted form of the Pediatric Sepsis Score (aPSS), a disease-specific severity score available within 60 min of PICU admission, in children with invasive infection. aPSS consist of all components of PSS except lactate. aPSS predicted mortality in children with invasive infection (n = 4096; AUC 0.70 (95% CI 0.67–0.73)) and in children with sepsis (n = 1690; AUC 0.71 (0.67–0.76)). aPSS can be an adequate tool to predict outcome in children admitted to PICU with invasive infection or sepsis, especially in situations where lactate is not available within 60 min. BioMed Central 2022-06-07 /pmc/articles/PMC9172174/ /pubmed/35672773 http://dx.doi.org/10.1186/s40560-022-00618-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Boeddha, Navin P.
Schlapbach, Luregn J.
Visser, Idse H.
Jansen, Nicolaas J. G.
Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
title Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
title_full Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
title_fullStr Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
title_full_unstemmed Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
title_short Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort
title_sort validation of an adapted pediatric sepsis score in children admitted to picu with invasive infection and sepsis: a retrospective analysis of a dutch national cohort
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172174/
https://www.ncbi.nlm.nih.gov/pubmed/35672773
http://dx.doi.org/10.1186/s40560-022-00618-3
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