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A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats

Sleep disruption is a challenging and exceedingly common physiological state that contributes to a wide range of biochemical and molecular perturbations and has been linked to numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, inc...

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Autores principales: Bowers, Samuel J., Summa, Keith C., Thompson, Robert S., González, Antonio, Vargas, Fernando, Olker, Christopher, Jiang, Peng, Lowry, Christopher A., Dorrestein, Pieter C., Knight, Rob, Wright, Kenneth P., Fleshner, Monika, Turek, Fred W., Vitaterna, Martha H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172596/
https://www.ncbi.nlm.nih.gov/pubmed/35685770
http://dx.doi.org/10.3389/fnins.2022.889211
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author Bowers, Samuel J.
Summa, Keith C.
Thompson, Robert S.
González, Antonio
Vargas, Fernando
Olker, Christopher
Jiang, Peng
Lowry, Christopher A.
Dorrestein, Pieter C.
Knight, Rob
Wright, Kenneth P.
Fleshner, Monika
Turek, Fred W.
Vitaterna, Martha H.
author_facet Bowers, Samuel J.
Summa, Keith C.
Thompson, Robert S.
González, Antonio
Vargas, Fernando
Olker, Christopher
Jiang, Peng
Lowry, Christopher A.
Dorrestein, Pieter C.
Knight, Rob
Wright, Kenneth P.
Fleshner, Monika
Turek, Fred W.
Vitaterna, Martha H.
author_sort Bowers, Samuel J.
collection PubMed
description Sleep disruption is a challenging and exceedingly common physiological state that contributes to a wide range of biochemical and molecular perturbations and has been linked to numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, including exposure to electric light, psychological stressors, technological interconnection, jet travel, shift work, and widespread use of sleep-affecting compounds. Interestingly, recent research has identified a link between the microbiome and the regulation of sleep, suggesting that interventions targeting the microbiome may offer unique therapeutic approaches to challenges posed by sleep disruption. In this study, we test the hypothesis that administration of a prebiotic diet containing galactooligosaccharides (GOS) and polydextrose (PDX) in adult male rats improves sleep in response to repeated sleep disruption and during recovery sleep. We found that animals fed the GOS/PDX prebiotic diet for 4 weeks exhibit increased non-rapid eye movement (NREM) and rapid eye movement (REM) sleep during 5 days of sleep disruption and increased total sleep time during 24 h of recovery from sleep disruption compared to animals fed a control diet, despite similar baseline sleep characteristics. Further, the GOS/PDX prebiotic diet led to significant changes in the fecal microbiome. Consistent with previous reports, the prebiotic diet increased the relative abundance of the species Parabacteroides distasonis, which positively correlated with sleep parameters during recovery sleep. Taken together, these findings suggest that the GOS/PDX prebiotic diet may offer an approach to improve resilience to the physiologic challenge of sleep disruption, in part through impacts on the microbiome.
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spelling pubmed-91725962022-06-08 A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats Bowers, Samuel J. Summa, Keith C. Thompson, Robert S. González, Antonio Vargas, Fernando Olker, Christopher Jiang, Peng Lowry, Christopher A. Dorrestein, Pieter C. Knight, Rob Wright, Kenneth P. Fleshner, Monika Turek, Fred W. Vitaterna, Martha H. Front Neurosci Neuroscience Sleep disruption is a challenging and exceedingly common physiological state that contributes to a wide range of biochemical and molecular perturbations and has been linked to numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, including exposure to electric light, psychological stressors, technological interconnection, jet travel, shift work, and widespread use of sleep-affecting compounds. Interestingly, recent research has identified a link between the microbiome and the regulation of sleep, suggesting that interventions targeting the microbiome may offer unique therapeutic approaches to challenges posed by sleep disruption. In this study, we test the hypothesis that administration of a prebiotic diet containing galactooligosaccharides (GOS) and polydextrose (PDX) in adult male rats improves sleep in response to repeated sleep disruption and during recovery sleep. We found that animals fed the GOS/PDX prebiotic diet for 4 weeks exhibit increased non-rapid eye movement (NREM) and rapid eye movement (REM) sleep during 5 days of sleep disruption and increased total sleep time during 24 h of recovery from sleep disruption compared to animals fed a control diet, despite similar baseline sleep characteristics. Further, the GOS/PDX prebiotic diet led to significant changes in the fecal microbiome. Consistent with previous reports, the prebiotic diet increased the relative abundance of the species Parabacteroides distasonis, which positively correlated with sleep parameters during recovery sleep. Taken together, these findings suggest that the GOS/PDX prebiotic diet may offer an approach to improve resilience to the physiologic challenge of sleep disruption, in part through impacts on the microbiome. Frontiers Media S.A. 2022-05-24 /pmc/articles/PMC9172596/ /pubmed/35685770 http://dx.doi.org/10.3389/fnins.2022.889211 Text en Copyright © 2022 Bowers, Summa, Thompson, González, Vargas, Olker, Jiang, Lowry, Dorrestein, Knight, Wright, Fleshner, Turek and Vitaterna. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bowers, Samuel J.
Summa, Keith C.
Thompson, Robert S.
González, Antonio
Vargas, Fernando
Olker, Christopher
Jiang, Peng
Lowry, Christopher A.
Dorrestein, Pieter C.
Knight, Rob
Wright, Kenneth P.
Fleshner, Monika
Turek, Fred W.
Vitaterna, Martha H.
A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
title A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
title_full A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
title_fullStr A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
title_full_unstemmed A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
title_short A Prebiotic Diet Alters the Fecal Microbiome and Improves Sleep in Response to Sleep Disruption in Rats
title_sort prebiotic diet alters the fecal microbiome and improves sleep in response to sleep disruption in rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172596/
https://www.ncbi.nlm.nih.gov/pubmed/35685770
http://dx.doi.org/10.3389/fnins.2022.889211
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