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Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial
BACKGROUND: Individualization using different volumes of polyethylene glycol is widely regarded as the optimal solution for bowel preparation, while the patient-directed regimen we propose may serve as a reliable individual solution. This study aimed to assess the efficacy, safety, and satisfaction...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172656/ https://www.ncbi.nlm.nih.gov/pubmed/35694717 http://dx.doi.org/10.1093/pcmedi/pbac009 |
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author | Zhang, Jixiang Jia, Xuemei Guo, Yuanmei Jiang, Haotian Hu, Jiaming Wang, Siwei Huang, Binglu Su, Wenhao Liu, Jun Wang, Xiaoli Dong, Weiguo |
author_facet | Zhang, Jixiang Jia, Xuemei Guo, Yuanmei Jiang, Haotian Hu, Jiaming Wang, Siwei Huang, Binglu Su, Wenhao Liu, Jun Wang, Xiaoli Dong, Weiguo |
author_sort | Zhang, Jixiang |
collection | PubMed |
description | BACKGROUND: Individualization using different volumes of polyethylene glycol is widely regarded as the optimal solution for bowel preparation, while the patient-directed regimen we propose may serve as a reliable individual solution. This study aimed to assess the efficacy, safety, and satisfaction of bowel preparation with a patient-directed regimen. METHODS: Patients in the fixed-volume group ingested the same amount of PEG, while those in patient-directed group ingested different amount according to stool consistency or stool water content. RESULTS: After filtering by exclusion criteria, 428 individuals in the fixed-volume group and 103 in the patient-directed group were successfully enrolled and analyzed. Eighty-three (80.6%) individuals in the patient-directed group had a reduced polyethylene glycol volume. There was no significant difference in the bowel preparation efficacy between the two groups (90.0% vs. 90.3%, χ² = 0.01; p = 0.918). Patients in the patient-directed group complained of fewer adverse effects (53.0% vs. 36.9%, χ² = 8.655; p = 0.003), especially vomiting (13.6% vs. 1.0%, χ² = 13.304; p < 0.001). Regarding comfort during bowel preparation, the degree of comfort was not significantly different between groups. Furthermore, the willingness rate for further colonoscopy in the patient-directed group was significantly higher than that in the fixed-volume group (90.3% vs. 77.1%, χ² = 8.912; p < 0.05). Multivariable logistic regression analysis showed that the body mass index served as an independent factor impacting quality of bowel preparation with the patient-directed regimen (OR 1.16, 95% CI 1.00–1.34; p = 0.043). CONCLUSIONS: Without decreasing the bowel preparation efficacy, the patient-directed regimen increased the safety and satisfaction of bowel preparation and is expected to be a regular and individual solution for bowel preparation. Individuals with a lower body mass index are more likely to undertake this new regimen. TRIAL REGISTRATION NUMBER: ChiCTR1900022072 at ChiClinicalTrials.gov |
format | Online Article Text |
id | pubmed-9172656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91726562022-06-10 Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial Zhang, Jixiang Jia, Xuemei Guo, Yuanmei Jiang, Haotian Hu, Jiaming Wang, Siwei Huang, Binglu Su, Wenhao Liu, Jun Wang, Xiaoli Dong, Weiguo Precis Clin Med Clinical Trial BACKGROUND: Individualization using different volumes of polyethylene glycol is widely regarded as the optimal solution for bowel preparation, while the patient-directed regimen we propose may serve as a reliable individual solution. This study aimed to assess the efficacy, safety, and satisfaction of bowel preparation with a patient-directed regimen. METHODS: Patients in the fixed-volume group ingested the same amount of PEG, while those in patient-directed group ingested different amount according to stool consistency or stool water content. RESULTS: After filtering by exclusion criteria, 428 individuals in the fixed-volume group and 103 in the patient-directed group were successfully enrolled and analyzed. Eighty-three (80.6%) individuals in the patient-directed group had a reduced polyethylene glycol volume. There was no significant difference in the bowel preparation efficacy between the two groups (90.0% vs. 90.3%, χ² = 0.01; p = 0.918). Patients in the patient-directed group complained of fewer adverse effects (53.0% vs. 36.9%, χ² = 8.655; p = 0.003), especially vomiting (13.6% vs. 1.0%, χ² = 13.304; p < 0.001). Regarding comfort during bowel preparation, the degree of comfort was not significantly different between groups. Furthermore, the willingness rate for further colonoscopy in the patient-directed group was significantly higher than that in the fixed-volume group (90.3% vs. 77.1%, χ² = 8.912; p < 0.05). Multivariable logistic regression analysis showed that the body mass index served as an independent factor impacting quality of bowel preparation with the patient-directed regimen (OR 1.16, 95% CI 1.00–1.34; p = 0.043). CONCLUSIONS: Without decreasing the bowel preparation efficacy, the patient-directed regimen increased the safety and satisfaction of bowel preparation and is expected to be a regular and individual solution for bowel preparation. Individuals with a lower body mass index are more likely to undertake this new regimen. TRIAL REGISTRATION NUMBER: ChiCTR1900022072 at ChiClinicalTrials.gov Oxford University Press 2022-05-25 /pmc/articles/PMC9172656/ /pubmed/35694717 http://dx.doi.org/10.1093/pcmedi/pbac009 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions.com |
spellingShingle | Clinical Trial Zhang, Jixiang Jia, Xuemei Guo, Yuanmei Jiang, Haotian Hu, Jiaming Wang, Siwei Huang, Binglu Su, Wenhao Liu, Jun Wang, Xiaoli Dong, Weiguo Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial |
title | Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial |
title_full | Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial |
title_fullStr | Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial |
title_full_unstemmed | Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial |
title_short | Patient-directed vs. fixed-volume PEG for colonoscopy preparation: a randomized controlled trial |
title_sort | patient-directed vs. fixed-volume peg for colonoscopy preparation: a randomized controlled trial |
topic | Clinical Trial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172656/ https://www.ncbi.nlm.nih.gov/pubmed/35694717 http://dx.doi.org/10.1093/pcmedi/pbac009 |
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