Cargando…

Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China

Despite few human cases of tick-borne encephalitis virus (TBEV), high rates of TBEV seroprevalence were reported among humans and animals in Xinjiang Uygur Autonomous Region in Northwestern China. In this study, the Karshi virus (KSIV) was identified and isolated from Hyalomma asiaticum ticks in Xin...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yuan, Zhang, Yanfang, Su, Zhengyuan, Tang, Shuang, Wang, Jun, Wu, Qiaoli, Yang, Juan, Moming, Abulimiti, Zhang, Yujiang, Bell-Sakyi, Lesley, Sun, Surong, Shen, Shu, Deng, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173002/
https://www.ncbi.nlm.nih.gov/pubmed/35685931
http://dx.doi.org/10.3389/fmicb.2022.872067
_version_ 1784721943584309248
author Bai, Yuan
Zhang, Yanfang
Su, Zhengyuan
Tang, Shuang
Wang, Jun
Wu, Qiaoli
Yang, Juan
Moming, Abulimiti
Zhang, Yujiang
Bell-Sakyi, Lesley
Sun, Surong
Shen, Shu
Deng, Fei
author_facet Bai, Yuan
Zhang, Yanfang
Su, Zhengyuan
Tang, Shuang
Wang, Jun
Wu, Qiaoli
Yang, Juan
Moming, Abulimiti
Zhang, Yujiang
Bell-Sakyi, Lesley
Sun, Surong
Shen, Shu
Deng, Fei
author_sort Bai, Yuan
collection PubMed
description Despite few human cases of tick-borne encephalitis virus (TBEV), high rates of TBEV seroprevalence were reported among humans and animals in Xinjiang Uygur Autonomous Region in Northwestern China. In this study, the Karshi virus (KSIV) was identified and isolated from Hyalomma asiaticum ticks in Xinjiang. It belongs to the genus Flavivirus of the family Flaviviridae and is closely related to TBEV. KSIV infects cell lines from humans, other mammals and ticks, and causes encephalitis in suckling mice. High minimum infection rates (4.96%) with KSIV were detected among tick groups. KSIV infections have occurred in sheep and marmots, resulting in antibody-positive rates of 2.43 and 2.56%, respectively. We further found that, of the KSIV antibody-positive serum samples from animals, 13.9% had TBEV exposure showing cross-reaction to KSIV, and 11.1% had KSIV infection resulting in cross-reaction to TBEV; 8.3% were likely to have co-exposure to both viruses (or may be infected with one of them and present cross-reactivity with the other). The results revealed a substantial KSIV prevalence among ticks in Xinjiang, indicating exposure of animals to KSIV and TBEV. The findings implied misinterpretation of the high rates of TBEV seroprevalence among humans and animals in previous studies. There is a need to develop detection methods to distinguish KSIV from TBEV and to perform an in-depth investigation of KSIV and TBEV prevalence and incidence in Northwestern China, which would enhance our preparation to provide medical treatment of emerging diseases caused by tick-borne viral pathogens such as KSIV.
format Online
Article
Text
id pubmed-9173002
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91730022022-06-08 Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China Bai, Yuan Zhang, Yanfang Su, Zhengyuan Tang, Shuang Wang, Jun Wu, Qiaoli Yang, Juan Moming, Abulimiti Zhang, Yujiang Bell-Sakyi, Lesley Sun, Surong Shen, Shu Deng, Fei Front Microbiol Microbiology Despite few human cases of tick-borne encephalitis virus (TBEV), high rates of TBEV seroprevalence were reported among humans and animals in Xinjiang Uygur Autonomous Region in Northwestern China. In this study, the Karshi virus (KSIV) was identified and isolated from Hyalomma asiaticum ticks in Xinjiang. It belongs to the genus Flavivirus of the family Flaviviridae and is closely related to TBEV. KSIV infects cell lines from humans, other mammals and ticks, and causes encephalitis in suckling mice. High minimum infection rates (4.96%) with KSIV were detected among tick groups. KSIV infections have occurred in sheep and marmots, resulting in antibody-positive rates of 2.43 and 2.56%, respectively. We further found that, of the KSIV antibody-positive serum samples from animals, 13.9% had TBEV exposure showing cross-reaction to KSIV, and 11.1% had KSIV infection resulting in cross-reaction to TBEV; 8.3% were likely to have co-exposure to both viruses (or may be infected with one of them and present cross-reactivity with the other). The results revealed a substantial KSIV prevalence among ticks in Xinjiang, indicating exposure of animals to KSIV and TBEV. The findings implied misinterpretation of the high rates of TBEV seroprevalence among humans and animals in previous studies. There is a need to develop detection methods to distinguish KSIV from TBEV and to perform an in-depth investigation of KSIV and TBEV prevalence and incidence in Northwestern China, which would enhance our preparation to provide medical treatment of emerging diseases caused by tick-borne viral pathogens such as KSIV. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9173002/ /pubmed/35685931 http://dx.doi.org/10.3389/fmicb.2022.872067 Text en Copyright © 2022 Bai, Zhang, Su, Tang, Wang, Wu, Yang, Moming, Zhang, Bell-Sakyi, Sun, Shen and Deng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bai, Yuan
Zhang, Yanfang
Su, Zhengyuan
Tang, Shuang
Wang, Jun
Wu, Qiaoli
Yang, Juan
Moming, Abulimiti
Zhang, Yujiang
Bell-Sakyi, Lesley
Sun, Surong
Shen, Shu
Deng, Fei
Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China
title Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China
title_full Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China
title_fullStr Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China
title_full_unstemmed Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China
title_short Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China
title_sort discovery of tick-borne karshi virus implies misinterpretation of the tick-borne encephalitis virus seroprevalence in northwest china
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173002/
https://www.ncbi.nlm.nih.gov/pubmed/35685931
http://dx.doi.org/10.3389/fmicb.2022.872067
work_keys_str_mv AT baiyuan discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT zhangyanfang discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT suzhengyuan discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT tangshuang discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT wangjun discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT wuqiaoli discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT yangjuan discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT momingabulimiti discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT zhangyujiang discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT bellsakyilesley discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT sunsurong discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT shenshu discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina
AT dengfei discoveryoftickbornekarshivirusimpliesmisinterpretationofthetickborneencephalitisvirusseroprevalenceinnorthwestchina