Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-γ in a predominantly hepatic-intrinsic manner

Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway ameliorates FHL hepatitis, both in animal models and in humans with FHL. Hepatocytes are known to express IFN-γ receptor (IFN-γ-R). However, whether...

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Detalles Bibliográficos
Autores principales: Diamond, Tamir, Burn, Thomas N., Nishiguchi, Mailyn A., Minichino, Danielle, Chase, Julie, Chu, Niansheng, Kreiger, Portia A., Behrens, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173616/
https://www.ncbi.nlm.nih.gov/pubmed/35671274
http://dx.doi.org/10.1371/journal.pone.0269553

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