Cargando…

Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in adolescent rats

Development of self-regulatory competencies during adolescence is partially dependent on normative brain maturation. Here, we report that adolescent rats as compared to adults exhibit impulsive and compulsive-like behavioral traits, the latter being associated with lower expression of mRNA levels of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jadhav, Kshitij S., Bernheim, Aurélien P., Aeschlimann, Léa, Kirschmann, Guylène, Decosterd, Isabelle, Hoffman, Alexander F., Lupica, Carl R., Boutrel, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173752/ https://www.ncbi.nlm.nih.gov/pubmed/35584117 http://dx.doi.org/10.1073/pnas.2121247119

Ejemplares similares

An orbitofrontal cortex–anterior insular cortex circuit gates compulsive cocaine use
por: Chen, Yang, et al.
Publicado: (2022)

Specific motor cortex hypoexcitability and hypoactivation in COPD patients with peripheral muscle weakness
por: Alexandre, Francois, et al.
Publicado: (2020)

Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex
por: Yamawaki, Yuki, et al.
Publicado: (2022)

Disproportionate Alterations in the Anterior and Posterior Insular Cortices in Obsessive–Compulsive Disorder
por: Song, Aram, et al.
Publicado: (2011)

Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model
por: Curto-Reyes, Verdad, et al.
Publicado: (2015)

Controversies about the enhanced vulnerability of the adolescent brain to develop addiction
por: Bernheim, Aurélien, et al.
Publicado: (2013)

Anterior insular cortex regulation in autism spectrum disorders
por: Caria, Andrea, et al.
Publicado: (2015)

The anterior insular cortex processes social recognition memory
por: Min, Ji-You, et al.
Publicado: (2023)

The Role of the Anterior Cingulate Cortex and Insular Cortex in Suicidal Memory and Intent
por: Parisi, Sara, et al.
Publicado: (2021)

Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response
por: Medford, Nick, et al.
Publicado: (2010)

The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na(V)1.7 via the Ubiquitin-Ligase NEDD4-2
por: Deftu, Alexandru-Florian, et al.
Publicado: (2022)

Spinal Cord T-Cell Infiltration in the Rat Spared Nerve Injury Model: A Time Course Study
por: Gattlen, Christophe, et al.
Publicado: (2016)

Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury
por: Konnova, Elena A., et al.
Publicado: (2023)

Cortical Hypoexcitation Defines Neuronal Responses in the Immediate Aftermath of Traumatic Brain Injury
por: Johnstone, Victoria Philippa Anne, et al.
Publicado: (2013)

Structural basis of empathy and the domain general region in the anterior insular cortex
por: Mutschler, Isabella, et al.
Publicado: (2013)

Anterior insular cortex plays a critical role in interoceptive attention
por: Wang, Xingchao, et al.
Publicado: (2019)

Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats
por: Bai, Yang, et al.
Publicado: (2019)

Role of the anterior insular cortex in restraint-stress induced fear behaviors
por: Park, Sanggeon, et al.
Publicado: (2022)

The role of anterior insular cortex inputs to dorsolateral striatum in binge alcohol drinking
por: Haggerty, David L, et al.
Publicado: (2022)

The Role of the Insular Cortex in Retaliation
por: Emmerling, Franziska, et al.
Publicado: (2016)

The Organization of the Primate Insular Cortex
por: Evrard, Henry C.
Publicado: (2019)

The Role of the Insular Cortex in Pain
por: Labrakakis, Charalampos
Publicado: (2023)

Immunoception: the insular cortex perspective
por: Rolls, Asya
Publicado: (2023)

Anterior insular cortex activity to emotional salience of voices in a passive oddball paradigm
por: Chen, Chenyi, et al.
Publicado: (2014)

The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice
por: Wu, Yu, et al.
Publicado: (2020)

Glutamatergic basolateral amygdala to anterior insular cortex circuitry maintains rewarding contextual memory
por: Gil-Lievana, Elvi, et al.
Publicado: (2020)

Primate anterior insular cortex represents economic decision variables proposed by prospect theory
por: Yang, You-Ping, et al.
Publicado: (2022)

Reduced anterior insular cortex volume in male heroin addicts: a postmortem study
por: Müller, Ulf J., et al.
Publicado: (2023)

CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice
por: Ma, Yingping, et al.
Publicado: (2023)

Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin
por: Sundberg, Maria, et al.
Publicado: (2018)

A preclinical model for identifying rats at risk of alcohol use disorder
por: Jadhav, Kshitij S., et al.
Publicado: (2017)

Food related processes in the insular cortex
por: Frank, Sabine, et al.
Publicado: (2013)

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
por: Martínez-Silva, María de Lourdes, et al.
Publicado: (2018)

Towards a machine‐learning assisted diagnosis of psychiatric disorders and their operationalization in preclinical research: Evidence from studies on addiction‐like behaviour in individual rats
por: Jadhav, Kshitij S., et al.
Publicado: (2022)

Neurofeedback of the difference in activation of the anterior cingulate cortex and posterior insular cortex: two functionally connected areas in the processing of pain
por: Rance, Mariela, et al.
Publicado: (2014)

Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity
por: Chen, Yan-Fen, et al.
Publicado: (2022)

A Critical Involvement of Glutamatergic Neurons in the Anterior Insular Cortex for Subdiaphragmatic Vagotomy-induced Analgesia
por: Kim, Yea Jin, et al.
Publicado: (2023)

Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients
por: Alari, Valentina, et al.
Publicado: (2021)

Transcriptomic Characterization of the Human Insular Cortex and Claustrum
por: Ibrahim, Christine, et al.
Publicado: (2019)

Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
por: Chao, Tzu-Hao Harry, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uk1vi3duddsqa0iv9hnoet0mle