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Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients

Chemokine receptor nanoscale organization at the cell membrane is orchestrated by the actin cytoskeleton and influences cell responses. Using single-particle tracking analysis we show that CXCR4(R334X), a truncated mutant chemokine receptor linked to WHIM syndrome (warts, hypogammaglobulinemia, infe...

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Detalles Bibliográficos
Autores principales:	García-Cuesta, Eva M., Rodríguez-Frade, José Miguel, Gardeta, Sofía R., D’Agostino, Gianluca, Martínez, Pablo, Soler Palacios, Blanca, Cascio, Graciela, Wolf, Tobias, Mateos, Nicolas, Ayala-Bueno, Rosa, Santiago, César A., Lucas, Pilar, Llorente, Lucia, Allende, Luis M., González-Granado, Luis Ignacio, Martín-Cófreces, Noa, Roda-Navarro, Pedro, Sallusto, Federica, Sánchez-Madrid, Francisco, García-Parajo, María F., Martínez-Muñoz, Laura, Mellado, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173760/ https://www.ncbi.nlm.nih.gov/pubmed/35588454 http://dx.doi.org/10.1073/pnas.2119483119

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