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Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex

Crossover formation is essential for proper segregation of homologous chromosomes during meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with cyclin-like protein COSA-1 to promote crossover formation by promoting conversion of meiotic double-strand break...

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Detalles Bibliográficos
Autores principales: Haversat, Jocelyn, Woglar, Alexander, Klatt, Kayla, Akerib, Chantal C., Roberts, Victoria, Chen, Shin-Yu, Arur, Swathi, Villeneuve, Anne M., Kim, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173770/
https://www.ncbi.nlm.nih.gov/pubmed/35576467
http://dx.doi.org/10.1073/pnas.2117865119