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Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications

The prevalence of Parkinson's disease (PD) tends to increase worldwide in the coming decades. Thus, the incidence of falls is likely to increase, with a relevant burden on the health care system. OBJECTIVE: The objective of this study was to evaluate clinical factors and drug use associated wit...

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Autores principales: Lima, Danielle Pessoa, de-Almeida, Samuel Brito, Bonfadini, Janine de Carvalho, Carneiro, Alexandre Henrique Silva, de Luna, João Rafael Gomes, de Alencar, Madeleine Sales, Viana-Júnior, Antonio Brazil, Rodrigues, Pedro Gustavo Barros, Pereira, Isabelle de Sousa, Roriz-Filho, Jarbas de Sá, Sobreira-Neto, Manoel Alves, Braga-Neto, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173793/
https://www.ncbi.nlm.nih.gov/pubmed/35720647
http://dx.doi.org/10.1590/1980-5764-DN-2021-0019
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author Lima, Danielle Pessoa
de-Almeida, Samuel Brito
Bonfadini, Janine de Carvalho
Carneiro, Alexandre Henrique Silva
de Luna, João Rafael Gomes
de Alencar, Madeleine Sales
Viana-Júnior, Antonio Brazil
Rodrigues, Pedro Gustavo Barros
Pereira, Isabelle de Sousa
Roriz-Filho, Jarbas de Sá
Sobreira-Neto, Manoel Alves
Braga-Neto, Pedro
author_facet Lima, Danielle Pessoa
de-Almeida, Samuel Brito
Bonfadini, Janine de Carvalho
Carneiro, Alexandre Henrique Silva
de Luna, João Rafael Gomes
de Alencar, Madeleine Sales
Viana-Júnior, Antonio Brazil
Rodrigues, Pedro Gustavo Barros
Pereira, Isabelle de Sousa
Roriz-Filho, Jarbas de Sá
Sobreira-Neto, Manoel Alves
Braga-Neto, Pedro
author_sort Lima, Danielle Pessoa
collection PubMed
description The prevalence of Parkinson's disease (PD) tends to increase worldwide in the coming decades. Thus, the incidence of falls is likely to increase, with a relevant burden on the health care system. OBJECTIVE: The objective of this study was to evaluate clinical factors and drug use associated with falls in PD patients. METHODS: We conducted a cross-sectional study at the Movement Disorders outpatient clinic of a tertiary hospital in Northeast Brazil. We performed structured interviews to collect sociodemographic and clinical data. Functional capacity was assessed using the Schwab and England Activities of Daily Living Scale and the modified Hoehn and Yahr Staging Scale. We divided the study sample into non-fallers (no falls) and fallers (≥1 fall), and non-recurrent (≤1 fall) and recurrent fallers (>1 fall). RESULTS: The study population comprised 327 PD patients (48% women), with a mean age of 70 years. The mean disease duration was 9.9±6.9 years. The most prevalent comorbidities were depression (47.2%), hypertension (44.0%), and type 2 diabetes mellitus (21.5%). The logistic regression analysis revealed that hallucinations, amantadine, and catechol-O-methyltransferase inhibitors (entacapone) were independently associated with falls in PD patients. Also, hallucinations, dyskinesia, and the use of amantadine were independently associated with recurrent falls. CONCLUSIONS: Health care providers play an essential role in fall prevention in PD patients, particularly by identifying older adults experiencing dyskinesia and visual hallucinations. Prospective studies should investigate the use of amantadine as a risk factor for falls in PD patients.
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spelling pubmed-91737932022-06-17 Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications Lima, Danielle Pessoa de-Almeida, Samuel Brito Bonfadini, Janine de Carvalho Carneiro, Alexandre Henrique Silva de Luna, João Rafael Gomes de Alencar, Madeleine Sales Viana-Júnior, Antonio Brazil Rodrigues, Pedro Gustavo Barros Pereira, Isabelle de Sousa Roriz-Filho, Jarbas de Sá Sobreira-Neto, Manoel Alves Braga-Neto, Pedro Dement Neuropsychol Original Article The prevalence of Parkinson's disease (PD) tends to increase worldwide in the coming decades. Thus, the incidence of falls is likely to increase, with a relevant burden on the health care system. OBJECTIVE: The objective of this study was to evaluate clinical factors and drug use associated with falls in PD patients. METHODS: We conducted a cross-sectional study at the Movement Disorders outpatient clinic of a tertiary hospital in Northeast Brazil. We performed structured interviews to collect sociodemographic and clinical data. Functional capacity was assessed using the Schwab and England Activities of Daily Living Scale and the modified Hoehn and Yahr Staging Scale. We divided the study sample into non-fallers (no falls) and fallers (≥1 fall), and non-recurrent (≤1 fall) and recurrent fallers (>1 fall). RESULTS: The study population comprised 327 PD patients (48% women), with a mean age of 70 years. The mean disease duration was 9.9±6.9 years. The most prevalent comorbidities were depression (47.2%), hypertension (44.0%), and type 2 diabetes mellitus (21.5%). The logistic regression analysis revealed that hallucinations, amantadine, and catechol-O-methyltransferase inhibitors (entacapone) were independently associated with falls in PD patients. Also, hallucinations, dyskinesia, and the use of amantadine were independently associated with recurrent falls. CONCLUSIONS: Health care providers play an essential role in fall prevention in PD patients, particularly by identifying older adults experiencing dyskinesia and visual hallucinations. Prospective studies should investigate the use of amantadine as a risk factor for falls in PD patients. Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2022-04-29 2022 /pmc/articles/PMC9173793/ /pubmed/35720647 http://dx.doi.org/10.1590/1980-5764-DN-2021-0019 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Lima, Danielle Pessoa
de-Almeida, Samuel Brito
Bonfadini, Janine de Carvalho
Carneiro, Alexandre Henrique Silva
de Luna, João Rafael Gomes
de Alencar, Madeleine Sales
Viana-Júnior, Antonio Brazil
Rodrigues, Pedro Gustavo Barros
Pereira, Isabelle de Sousa
Roriz-Filho, Jarbas de Sá
Sobreira-Neto, Manoel Alves
Braga-Neto, Pedro
Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
title Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
title_full Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
title_fullStr Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
title_full_unstemmed Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
title_short Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
title_sort falls in parkinson's disease: the impact of disease progression, treatment, and motor complications
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173793/
https://www.ncbi.nlm.nih.gov/pubmed/35720647
http://dx.doi.org/10.1590/1980-5764-DN-2021-0019
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