Hydration-mediated G-protein–coupled receptor activation

The Rhodopsin family of G-protein–coupled receptors (GPCRs) comprises the targets of nearly a third of all pharmaceuticals. Despite structural water present in GPCR X-ray structures, the physiological relevance of these solvent molecules to rhodopsin signaling remains unknown. Here, we show experime...

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Detalles Bibliográficos
Autores principales: Fried, Steven D. E., Hewage, Kushani S. K., Eitel, Anna R., Struts, Andrey V., Weerasinghe, Nipuna, Perera, Suchithranga M. D. C., Brown, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173805/
https://www.ncbi.nlm.nih.gov/pubmed/35584119
http://dx.doi.org/10.1073/pnas.2117349119

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