ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling

The metazoan innate immune second messenger 2′3′-cGAMP is present both inside and outside cells. However, only extracellular cGAMP can be negatively regulated by the extracellular hydrolase ENPP1. Here, we determine whether ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of atten...

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Detalles Bibliográficos
Autores principales: Carozza, Jacqueline A., Cordova, Anthony F., Brown, Jenifer A., AlSaif, Yasmeen, Böhnert, Volker, Cao, Xujun, Mardjuki, Rachel E., Skariah, Gemini, Fernandez, Daniel, Li, Lingyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173814/
https://www.ncbi.nlm.nih.gov/pubmed/35588451
http://dx.doi.org/10.1073/pnas.2119189119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173814/
https://www.ncbi.nlm.nih.gov/pubmed/35588451
http://dx.doi.org/10.1073/pnas.2119189119

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