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ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
The metazoan innate immune second messenger 2′3′-cGAMP is present both inside and outside cells. However, only extracellular cGAMP can be negatively regulated by the extracellular hydrolase ENPP1. Here, we determine whether ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of atten...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173814/ https://www.ncbi.nlm.nih.gov/pubmed/35588451 http://dx.doi.org/10.1073/pnas.2119189119 |