Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health concern, and new treatment strategies are needed. Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4) a...

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Detalles Bibliográficos
Autores principales: Eltobgy, Mostafa M., Zani, Ashley, Kenney, Adam D., Estfanous, Shady, Kim, Eunsoo, Badr, Asmaa, Carafice, Cierra, Daily, Kylene, Whitham, Owen, Pietrzak, Maciej, Webb, Amy, Kawahara, Jeffrey, Eddy, Adrian C., Denz, Parker, Lu, Mijia, Mahesh, KC, Peeples, Mark E., Li, Jianrong, Zhu, Jian, Que, Jianwen, Robinson, Richard, Mejia, Oscar Rosas, Rayner, Rachael E., Hall-Stoodley, Luanne, Seveau, Stephanie, Gavrilin, Mikhail A., Zhang, Xiaoli, Thomas, Jeronay, Kohlmeier, Jacob E., Suthar, Mehul S., Oltz, Eugene, Tedeschi, Andrea, Robledo-Avila, Frank H., Partida-Sanchez, Santiago, Hemann, Emily A., Abdelrazik, Eman, Forero, Adriana, Nimjee, Shahid M., Boyaka, Prosper N., Cormet-Boyaka, Estelle, Yount, Jacob S., Amer, Amal O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173818/
https://www.ncbi.nlm.nih.gov/pubmed/35588457
http://dx.doi.org/10.1073/pnas.2202012119

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