Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

The coronavirus disease 2019 (COVID-19) pandemic continues to spread globally, highlighting the urgent need for safe and effective vaccines that could be rapidly mobilized to immunize large populations. We report the preclinical development of a self-amplifying mRNA (SAM) vaccine encoding a prefusio...

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Detalles Bibliográficos
Autores principales: Rappaport, Amy R., Hong, Sue-Jean, Scallan, Ciaran D., Gitlin, Leonid, Akoopie, Arvin, Boucher, Gregory R., Egorova, Milana, Espinosa, J. Aaron, Fidanza, Mario, Kachura, Melissa A., Shen, Annie, Sivko, Gloria, Van Abbema, Anne, Veres, Robert L., Jooss, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173840/
https://www.ncbi.nlm.nih.gov/pubmed/35672369
http://dx.doi.org/10.1038/s41467-022-31005-z

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