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Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure

Although some progress has been made in its treatment, heart failure is still one of the most important health problems that endanger public health. This study aims to explore the myocardial protective effect of secreted frizzled-related protein 5 (SFRP5) on mice with heart failure. The mouse model...

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Autores principales: Hong, Pan, Wang, Lijie, Wang, Hongchao, Shi, Min, Guo, Bingyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173992/
https://www.ncbi.nlm.nih.gov/pubmed/35685732
http://dx.doi.org/10.1155/2022/1606212
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author Hong, Pan
Wang, Lijie
Wang, Hongchao
Shi, Min
Guo, Bingyan
author_facet Hong, Pan
Wang, Lijie
Wang, Hongchao
Shi, Min
Guo, Bingyan
author_sort Hong, Pan
collection PubMed
description Although some progress has been made in its treatment, heart failure is still one of the most important health problems that endanger public health. This study aims to explore the myocardial protective effect of secreted frizzled-related protein 5 (SFRP5) on mice with heart failure. The mouse model of heart failure was established by using the isoproterenol (ISO) hydrochloride gradient modeling method. The treatment group was injected with 0.02 mg/kg/24 h SFRP5 recombinant protein intraperitoneally 30 minutes after the injection of isoproterenol, and the ISO + phosphate-buffered saline (PBS) group was injected with the same amount of PBS. After intraperitoneal injection of SFRP5 recombinant protein in mice with heart failure, the inflammatory response was reduced, and the left ventricular systolic and diastolic function of heart failure mice and the pathological structure of the myocardial tissue were improved. Compared with the ISO group, the expression level of SFRP5 protein in the ISO + SFRP5 group was increased significantly, the expression levels of Wnt5a and JNK protein were decreased markedly, and the enzyme activities of SOD and GSH-Px in the serum were observably increased, but they were lower than those parameters in the normal group. The SFRP5 recombinant protein has a protective effect on isoproterenol-induced heart failure in mice. The mechanism of action may be related to inhibiting the Wnt5A/JNK signaling pathway and reducing oxidative stress and inflammation. SFRP5 may be one of the therapeutic targets of heart failure.
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spelling pubmed-91739922022-06-08 Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure Hong, Pan Wang, Lijie Wang, Hongchao Shi, Min Guo, Bingyan Evid Based Complement Alternat Med Research Article Although some progress has been made in its treatment, heart failure is still one of the most important health problems that endanger public health. This study aims to explore the myocardial protective effect of secreted frizzled-related protein 5 (SFRP5) on mice with heart failure. The mouse model of heart failure was established by using the isoproterenol (ISO) hydrochloride gradient modeling method. The treatment group was injected with 0.02 mg/kg/24 h SFRP5 recombinant protein intraperitoneally 30 minutes after the injection of isoproterenol, and the ISO + phosphate-buffered saline (PBS) group was injected with the same amount of PBS. After intraperitoneal injection of SFRP5 recombinant protein in mice with heart failure, the inflammatory response was reduced, and the left ventricular systolic and diastolic function of heart failure mice and the pathological structure of the myocardial tissue were improved. Compared with the ISO group, the expression level of SFRP5 protein in the ISO + SFRP5 group was increased significantly, the expression levels of Wnt5a and JNK protein were decreased markedly, and the enzyme activities of SOD and GSH-Px in the serum were observably increased, but they were lower than those parameters in the normal group. The SFRP5 recombinant protein has a protective effect on isoproterenol-induced heart failure in mice. The mechanism of action may be related to inhibiting the Wnt5A/JNK signaling pathway and reducing oxidative stress and inflammation. SFRP5 may be one of the therapeutic targets of heart failure. Hindawi 2022-05-31 /pmc/articles/PMC9173992/ /pubmed/35685732 http://dx.doi.org/10.1155/2022/1606212 Text en Copyright © 2022 Pan Hong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hong, Pan
Wang, Lijie
Wang, Hongchao
Shi, Min
Guo, Bingyan
Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure
title Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure
title_full Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure
title_fullStr Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure
title_full_unstemmed Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure
title_short Effect of Secreted Frizzled-Related Protein 5 in Mice with Heart Failure
title_sort effect of secreted frizzled-related protein 5 in mice with heart failure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173992/
https://www.ncbi.nlm.nih.gov/pubmed/35685732
http://dx.doi.org/10.1155/2022/1606212
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