Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

The ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification of both effective targets for local immune modulation and a delivery system capable of crossing the bloo...

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Autores principales: Yshii, Lidia, Pasciuto, Emanuela, Bielefeld, Pascal, Mascali, Loriana, Lemaitre, Pierre, Marino, Marika, Dooley, James, Kouser, Lubna, Verschoren, Stijn, Lagou, Vasiliki, Kemps, Hannelore, Gervois, Pascal, de Boer, Antina, Burton, Oliver T., Wahis, Jérôme, Verhaert, Jens, Tareen, Samar H. K., Roca, Carlos P., Singh, Kailash, Whyte, Carly E., Kerstens, Axelle, Callaerts-Vegh, Zsuzsanna, Poovathingal, Suresh, Prezzemolo, Teresa, Wierda, Keimpe, Dashwood, Amy, Xie, Junhua, Van Wonterghem, Elien, Creemers, Eline, Aloulou, Meryem, Gsell, Willy, Abiega, Oihane, Munck, Sebastian, Vandenbroucke, Roosmarijn E., Bronckaers, Annelies, Lemmens, Robin, De Strooper, Bart, Van Den Bosch, Ludo, Himmelreich, Uwe, Fitzsimons, Carlos P., Holt, Matthew G., Liston, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174055/
https://www.ncbi.nlm.nih.gov/pubmed/35618831
http://dx.doi.org/10.1038/s41590-022-01208-z

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