Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and pH, multiplex confocal imaging and correlative light...

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Detalles Bibliográficos
Autores principales: Lee, Ju-Hyun, Yang, Dun-Sheng, Goulbourne, Chris N., Im, Eunju, Stavrides, Philip, Pensalfini, Anna, Chan, Han, Bouchet-Marquis, Cedric, Bleiwas, Cynthia, Berg, Martin J., Huo, Chunfeng, Peddy, James, Pawlik, Monika, Levy, Efrat, Rao, Mala, Staufenbiel, Mathias, Nixon, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174056/
https://www.ncbi.nlm.nih.gov/pubmed/35654956
http://dx.doi.org/10.1038/s41593-022-01084-8

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