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Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Aim: Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet...

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Autores principales: Umezawa, Ariko, Maruyama, Chizuko, Endo, Yasuhiro, Suenaga, Yumiko, Shijo, Yuri, Kameyama, Noriko, Sato, Aisa, Nishitani, Ai, Ayaori, Makoto, Waki, Masako, Teramoto, Tamio, Ikewaki, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174087/
https://www.ncbi.nlm.nih.gov/pubmed/34024872
http://dx.doi.org/10.5551/jat.62832
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author Umezawa, Ariko
Maruyama, Chizuko
Endo, Yasuhiro
Suenaga, Yumiko
Shijo, Yuri
Kameyama, Noriko
Sato, Aisa
Nishitani, Ai
Ayaori, Makoto
Waki, Masako
Teramoto, Tamio
Ikewaki, Katsunori
author_facet Umezawa, Ariko
Maruyama, Chizuko
Endo, Yasuhiro
Suenaga, Yumiko
Shijo, Yuri
Kameyama, Noriko
Sato, Aisa
Nishitani, Ai
Ayaori, Makoto
Waki, Masako
Teramoto, Tamio
Ikewaki, Katsunori
author_sort Umezawa, Ariko
collection PubMed
description Aim: Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations. Methods: A randomized parallel controlled clinical trial on JD intake was performed in Japanese patients with dyslipidemia. Ninety-eight participants were randomly divided into the JD (n=49) or the partial JD (PJD) (n=49) group. Nutrition education, based on each diet at baseline and at 3 months, was provided and the participants were followed up for 6 months. Results: Mean CEC was 1.05 in total and correlated positively with HDL-cholesterol (p<0.001) at baseline. CEC did not change while oxygen radical absorbance capacity (ORAC) was decreased in both groups (p<0.001). Although serum total carotenoid increased in both groups, serum α-tocopherol decreased in the JD group as compared to the PJD group (p<0.05). CEC correlated positively with HDL ORAC at baseline (p=0.021) and with serum total carotenoid at 3 and 6 months (p=0.005, 0.035). Changes in CEC correlated positively with changes in HDL ORAC at 3 months and serum total tocopherol at 3 and 6 months (p<0.001). Conclusion: CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum α- and γ-tocopherol and HDL ORAC.
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spelling pubmed-91740872022-07-05 Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial Umezawa, Ariko Maruyama, Chizuko Endo, Yasuhiro Suenaga, Yumiko Shijo, Yuri Kameyama, Noriko Sato, Aisa Nishitani, Ai Ayaori, Makoto Waki, Masako Teramoto, Tamio Ikewaki, Katsunori J Atheroscler Thromb Original Article Aim: Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations. Methods: A randomized parallel controlled clinical trial on JD intake was performed in Japanese patients with dyslipidemia. Ninety-eight participants were randomly divided into the JD (n=49) or the partial JD (PJD) (n=49) group. Nutrition education, based on each diet at baseline and at 3 months, was provided and the participants were followed up for 6 months. Results: Mean CEC was 1.05 in total and correlated positively with HDL-cholesterol (p<0.001) at baseline. CEC did not change while oxygen radical absorbance capacity (ORAC) was decreased in both groups (p<0.001). Although serum total carotenoid increased in both groups, serum α-tocopherol decreased in the JD group as compared to the PJD group (p<0.05). CEC correlated positively with HDL ORAC at baseline (p=0.021) and with serum total carotenoid at 3 and 6 months (p=0.005, 0.035). Changes in CEC correlated positively with changes in HDL ORAC at 3 months and serum total tocopherol at 3 and 6 months (p<0.001). Conclusion: CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum α- and γ-tocopherol and HDL ORAC. Japan Atherosclerosis Society 2022-06-01 2021-05-22 /pmc/articles/PMC9174087/ /pubmed/34024872 http://dx.doi.org/10.5551/jat.62832 Text en 2022 Japan Atherosclerosis Society https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Article
Umezawa, Ariko
Maruyama, Chizuko
Endo, Yasuhiro
Suenaga, Yumiko
Shijo, Yuri
Kameyama, Noriko
Sato, Aisa
Nishitani, Ai
Ayaori, Makoto
Waki, Masako
Teramoto, Tamio
Ikewaki, Katsunori
Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
title Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
title_full Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
title_fullStr Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
title_full_unstemmed Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
title_short Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
title_sort effects of dietary education program for the japan diet on cholesterol efflux capacity: a randomized controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174087/
https://www.ncbi.nlm.nih.gov/pubmed/34024872
http://dx.doi.org/10.5551/jat.62832
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