Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway

AIMS/HYPOTHESIS: During hyperglycaemia, some glucose bypasses glycolysis and is metabolised via the potentially neurotoxic polyol pathway, in which glucose is metabolised to sorbitol and fructose. Increased polyol concentrations have been demonstrated in the cerebrospinal fluid (CSF) of neurological...

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Detalles Bibliográficos
Autores principales: Tigchelaar, Celien, van Zuylen, Mark L., Hulst, Abraham H., Preckel, Benedikt, van Beek, André P., Kema, Ido P., Hermanides, Jeroen, Absalom, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174140/
https://www.ncbi.nlm.nih.gov/pubmed/35380232
http://dx.doi.org/10.1007/s00125-022-05693-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174140/
https://www.ncbi.nlm.nih.gov/pubmed/35380232
http://dx.doi.org/10.1007/s00125-022-05693-7

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