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Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway
AIMS/HYPOTHESIS: During hyperglycaemia, some glucose bypasses glycolysis and is metabolised via the potentially neurotoxic polyol pathway, in which glucose is metabolised to sorbitol and fructose. Increased polyol concentrations have been demonstrated in the cerebrospinal fluid (CSF) of neurological...
Autores principales: | Tigchelaar, Celien, van Zuylen, Mark L., Hulst, Abraham H., Preckel, Benedikt, van Beek, André P., Kema, Ido P., Hermanides, Jeroen, Absalom, Anthony R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174140/ https://www.ncbi.nlm.nih.gov/pubmed/35380232 http://dx.doi.org/10.1007/s00125-022-05693-7 |
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