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A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago
The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline essential for their biosynthesis. Here, we show...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174169/ https://www.ncbi.nlm.nih.gov/pubmed/35672295 http://dx.doi.org/10.1038/s41467-022-30856-w |
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author | Catania, Theresa Li, Yi Winzer, Thilo Harvey, David Meade, Fergus Caridi, Anna Leech, Andrew Larson, Tony R. Ning, Zemin Chang, Jiyang Van de Peer, Yves Graham, Ian A. |
author_facet | Catania, Theresa Li, Yi Winzer, Thilo Harvey, David Meade, Fergus Caridi, Anna Leech, Andrew Larson, Tony R. Ning, Zemin Chang, Jiyang Van de Peer, Yves Graham, Ian A. |
author_sort | Catania, Theresa |
collection | PubMed |
description | The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline essential for their biosynthesis. Here, we show that of the 12 Papaver species analysed those containing the STORR gene fusion also contain promorphinans/morphinans with one important exception. P. californicum encodes a functionally conserved STORR but does not produce promorphinans/morphinans. We also show that the gene fusion event occurred only once, between 16.8-24.1 million years ago before the separation of P. californicum from other Clade 2 Papaver species. The most abundant BIA in P. californicum is (R)-glaucine, a member of the aporphine subclass of BIAs, raising the possibility that STORR, once evolved, contributes to the biosynthesis of more than just the promorphinan/morphinan subclass of BIAs in the Papaveraceae. |
format | Online Article Text |
id | pubmed-9174169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91741692022-06-09 A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago Catania, Theresa Li, Yi Winzer, Thilo Harvey, David Meade, Fergus Caridi, Anna Leech, Andrew Larson, Tony R. Ning, Zemin Chang, Jiyang Van de Peer, Yves Graham, Ian A. Nat Commun Article The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline essential for their biosynthesis. Here, we show that of the 12 Papaver species analysed those containing the STORR gene fusion also contain promorphinans/morphinans with one important exception. P. californicum encodes a functionally conserved STORR but does not produce promorphinans/morphinans. We also show that the gene fusion event occurred only once, between 16.8-24.1 million years ago before the separation of P. californicum from other Clade 2 Papaver species. The most abundant BIA in P. californicum is (R)-glaucine, a member of the aporphine subclass of BIAs, raising the possibility that STORR, once evolved, contributes to the biosynthesis of more than just the promorphinan/morphinan subclass of BIAs in the Papaveraceae. Nature Publishing Group UK 2022-06-07 /pmc/articles/PMC9174169/ /pubmed/35672295 http://dx.doi.org/10.1038/s41467-022-30856-w Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Catania, Theresa Li, Yi Winzer, Thilo Harvey, David Meade, Fergus Caridi, Anna Leech, Andrew Larson, Tony R. Ning, Zemin Chang, Jiyang Van de Peer, Yves Graham, Ian A. A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago |
title | A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago |
title_full | A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago |
title_fullStr | A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago |
title_full_unstemmed | A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago |
title_short | A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago |
title_sort | functionally conserved storr gene fusion in papaver species that diverged 16.8 million years ago |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174169/ https://www.ncbi.nlm.nih.gov/pubmed/35672295 http://dx.doi.org/10.1038/s41467-022-30856-w |
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