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Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation

A distinct profile of NRAS mutants is observed in each tumor type. It is unclear whether these profiles are determined by mutagenic events or functional differences between NRAS oncoproteins. Here, we establish functional hallmarks of NRAS mutants enriched in human melanoma. We generate eight condit...

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Detalles Bibliográficos
Autores principales:	Murphy, Brandon M., Terrell, Elizabeth M., Chirasani, Venkat R., Weiss, Tirzah J., Lew, Rachel E., Holderbaum, Andrea M., Dhakal, Aastha, Posada, Valentina, Fort, Marie, Bodnar, Michael S., Carey, Leiah M., Chen, Min, Burd, Craig J., Coppola, Vincenzo, Morrison, Deborah K., Campbell, Sharon L., Burd, Christin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174180/ https://www.ncbi.nlm.nih.gov/pubmed/35672316 http://dx.doi.org/10.1038/s41467-022-30881-9

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