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Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling

Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) are associated with an increased risk of mortality and adverse cardiovascular outcomes. ADMA can be metabolized by dimethylarginine dimethylaminohydrolases (DDAHs) and by alanine-glyoxylate aminotransferase 2 (AGXT2). Deletion of D...

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Detalles Bibliográficos
Autores principales:	Rodionov, Roman N., Jarzebska, Natalia, Burdin, Dmitrii, Todorov, Vladimir, Martens-Lobenhoffer, Jens, Hofmann, Anja, Kolouschek, Anne, Cordasic, Nada, Jacobi, Johannes, Rubets, Elena, Morawietz, Henning, O’Sullivan, John F., Markov, Alexander G., Bornstein, Stefan R., Hilgers, Karl, Maas, Renke, Pfluecke, Christian, Chen, YingJie, Bode-Böger, Stefanie M., Hugo, Christian P. M., Hohenstein, Bernd, Weiss, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174227/ https://www.ncbi.nlm.nih.gov/pubmed/35672381 http://dx.doi.org/10.1038/s41598-022-13169-2

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