Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart failure, but it remains elusive whether there is a common pathway to induce both events. Through single-cell RNA-seq, spatial transcriptomics, and genetic perturbation, we elucidate that high-temperature requ...

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Detalles Bibliográficos
Autores principales: Ko, Toshiyuki, Nomura, Seitaro, Yamada, Shintaro, Fujita, Kanna, Fujita, Takanori, Satoh, Masahiro, Oka, Chio, Katoh, Manami, Ito, Masamichi, Katagiri, Mikako, Sassa, Tatsuro, Zhang, Bo, Hatsuse, Satoshi, Yamada, Takanobu, Harada, Mutsuo, Toko, Haruhiro, Amiya, Eisuke, Hatano, Masaru, Kinoshita, Osamu, Nawata, Kan, Abe, Hiroyuki, Ushiku, Tetsuo, Ono, Minoru, Ikeuchi, Masashi, Morita, Hiroyuki, Aburatani, Hiroyuki, Komuro, Issei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174232/
https://www.ncbi.nlm.nih.gov/pubmed/35672400
http://dx.doi.org/10.1038/s41467-022-30630-y

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