Cargando…

HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples

BACKGROUND: Biliary tract cancers (BTC) are rare but highly aggressive tumours with poor prognosis, usually detected at advanced stages. Herein, we aimed at identifying BTC-specific DNA methylation alterations. METHODS: Study design included statistical power and sample size estimation. A genome-wid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loi, Eleonora, Zavattari, Cesare, Tommasi, Alessandro, Moi, Loredana, Canale, Matteo, Po, Agnese, Sabato, Claudia, Vega-Benedetti, Ana Florencia, Ziranu, Pina, Puzzoni, Marco, Lai, Eleonora, Faloppi, Luca, Rullán, María, Carrascosa, Juan, Amat, Irene, Urman, Jesús M., Arechederra, Maria, Berasain, Carmen, Ferretti, Elisabetta, Casadei-Gardini, Andrea, Avila, Matías A., Alonso, Sergio, Scartozzi, Mario, Zavattari, Patrizia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174245/ https://www.ncbi.nlm.nih.gov/pubmed/35177798 http://dx.doi.org/10.1038/s41416-022-01738-1

Ejemplares similares

Colorectal Cancer Early Detection in Stool Samples Tracing CpG Islands Methylation Alterations Affecting Gene Expression
por: Vega-Benedetti, Ana Florencia, et al.
Publicado: (2020)

DNA methylation alterations at RE1-silencing transcription factor binding sites and their flanking regions in cancer
por: Vega-Benedetti, Ana Florencia, et al.
Publicado: (2023)

Colorectal cancer promoter methylation alteration affects the expression of glutamate ionotropic receptor AMPA type subunit 4 alternative isoforms potentially relevant in colon tissue
por: Vega-Benedetti, Ana Florencia, et al.
Publicado: (2021)

Clustered protocadherins methylation alterations in cancer
por: Vega-Benedetti, Ana Florencia, et al.
Publicado: (2019)

Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas
por: Antonelli, Manila, et al.
Publicado: (2018)

DNA methylation alterations caused by Leishmania infection may generate a microenvironment prone to tumour development
por: Vega-Benedetti, Ana Florencia, et al.
Publicado: (2022)

HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infections
por: Loi, Eleonora, et al.
Publicado: (2022)

ELMOD3‐SH2D6 gene fusion as a possible co‐star actor in autism spectrum disorder scenario
por: Loi, Eleonora, et al.
Publicado: (2019)

Relevance of Essential Trace Elements in Nutrition and Drinking Water for Human Health and Autoimmune Disease Risk
por: Cannas, Daniela, et al.
Publicado: (2020)

Circulating tumour DNA in gastrointestinal cancer in clinical practice: Just a dream or maybe not?
por: Pretta, Andrea, et al.
Publicado: (2022)

An Overview of the Main Genetic, Epigenetic and Environmental Factors Involved in Autism Spectrum Disorder Focusing on Synaptic Activity
por: Masini, Elena, et al.
Publicado: (2020)

Analysis of a Sardinian Multiplex Family with Autism Spectrum Disorder Points to Post-Synaptic Density Gene Variants and Identifies CAPG as a Functionally Relevant Candidate Gene
por: Bacchelli, Elena, et al.
Publicado: (2019)

Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities
por: Canale, Matteo, et al.
Publicado: (2020)

Estimation of a significance threshold for epigenome‐wide association studies
por: Saffari, Ayden, et al.
Publicado: (2017)

How to improve metastatic pancreatic ductal adenocarcinoma patients’ selection: Between clinical trials and the real-world
por: Pretta, Andrea, et al.
Publicado: (2022)

Correlation of HOXD3 promoter hypermethylation with clinical and pathologic features in screening prostate biopsies
por: Chen, Leonard N, et al.
Publicado: (2014)

Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma
por: Guo, Yulin, et al.
Publicado: (2017)

New Horizons in Metastatic Colorectal Cancer: Prognostic Role of CD44 Expression
por: Ziranu, Pina, et al.
Publicado: (2023)

Immune Checkpoint Inhibitors in the Treatment of HCC
por: Donisi, Clelia, et al.
Publicado: (2021)

Hepatocellular carcinoma and microbiota: Implications for clinical management and treatment
por: Spanu, Dario, et al.
Publicado: (2022)

Methylation alteration of SHANK1 as a predictive, diagnostic and prognostic biomarker for chronic lymphocytic leukemia
por: Loi, Eleonora, et al.
Publicado: (2019)

Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis
por: Sanna, Alessandro, et al.
Publicado: (2018)

The correlation between LDH serum levels and clinical outcome in advanced biliary tract cancer patients treated with first line chemotherapy
por: Faloppi, Luca, et al.
Publicado: (2016)

Lactate Dehydrogenase in Hepatocellular Carcinoma: Something Old, Something New
por: Faloppi, Luca, et al.
Publicado: (2016)

Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?
por: Claveria-Cabello, Alex, et al.
Publicado: (2020)

A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma
por: Wang, Lumin, et al.
Publicado: (2023)

Liquid biopsy for cancer management: a revolutionary but still limited new tool for precision medicine
por: Arechederra, María, et al.
Publicado: (2020)

La biopsia líquida en el manejo del cáncer: una nueva herramienta revolucionaria de la medicina de precisión, aún con limitaciones
por: Arechederra, María, et al.
Publicado: (2020)

Profile of lenvatinib in the treatment of hepatocellular carcinoma: design, development, potential place in therapy and network meta-analysis of hepatitis B and hepatitis C in all Phase III trials
por: Casadei Gardini, Andrea, et al.
Publicado: (2019)

Hoxd10 Is Required Systemically for Secretory Activation in Lactation and Interacts Genetically with Hoxd9
por: Landua, John D., et al.
Publicado: (2020)

Efficacy of sorafenib in BRAF-mutated non-small-cell lung cancer (NSCLC) and no response in synchronous BRAF wild type-hepatocellular carcinoma: a case report
por: Casadei Gardini, Andrea, et al.
Publicado: (2016)

Making HoxD waves
por: Katsnelson, Alla
Publicado: (2006)

Evx2-Hoxd13 Intergenic Region Restricts Enhancer Association to Hoxd13 Promoter
por: Yamagishi, Takumi, et al.
Publicado: (2007)

Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression
por: Guo, Liyuan, et al.
Publicado: (2017)

Survival trends over 20 years in patients with advanced cholangiocarcinoma: Results from a national retrospective analysis of 922 cases in Italy
por: Casadei-Gardini, Andrea, et al.
Publicado: (2023)

Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value
por: Citarella, Anna, et al.
Publicado: (2023)

Point Mutation of Hoxd12 in Mice
por: Cho, Kyoung-Won, et al.
Publicado: (2008)

BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives
por: Molinaro, Eleonora, et al.
Publicado: (2020)

Early onset of hypertension and serum electrolyte changes as potential predictive factors of activity in advanced HCC patients treated with sorafenib: results from a retrospective analysis of the HCC-AVR group
por: Gardini, Andrea Casadei, et al.
Publicado: (2016)

Immune inflammation indicators and implication for immune modulation strategies in advanced hepatocellular carcinoma patients receiving sorafenib
por: Gardini, Andrea Casadei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hbrarcpu4iihpger3iiai96cbh