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Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure

BACKGROUND: The aims of our study were (1) to assess the right ventricular (RV) myocardial mechanics by two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography (STE) in patients with an ischemic or non-ischemic etiology of end-stage heart failure (HF) and (2) to explore whi...

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Autores principales: Tian, Fangyan, Gu, Ying, Zhang, Yanting, Zhang, Bei, Xie, Yuji, Yu, Shaomei, Zhu, Shuangshuang, Sun, Wei, Cheng, Shan, Qian, Mingzu, Lin, Yixia, Wu, Wenqian, Yang, Yali, Lv, Qing, Wang, Jing, Zhang, Li, Li, Yuman, Xie, Mingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174453/
https://www.ncbi.nlm.nih.gov/pubmed/35694662
http://dx.doi.org/10.3389/fcvm.2022.765191
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author Tian, Fangyan
Gu, Ying
Zhang, Yanting
Zhang, Bei
Xie, Yuji
Yu, Shaomei
Zhu, Shuangshuang
Sun, Wei
Cheng, Shan
Qian, Mingzu
Lin, Yixia
Wu, Wenqian
Yang, Yali
Lv, Qing
Wang, Jing
Zhang, Li
Li, Yuman
Xie, Mingxing
author_facet Tian, Fangyan
Gu, Ying
Zhang, Yanting
Zhang, Bei
Xie, Yuji
Yu, Shaomei
Zhu, Shuangshuang
Sun, Wei
Cheng, Shan
Qian, Mingzu
Lin, Yixia
Wu, Wenqian
Yang, Yali
Lv, Qing
Wang, Jing
Zhang, Li
Li, Yuman
Xie, Mingxing
author_sort Tian, Fangyan
collection PubMed
description BACKGROUND: The aims of our study were (1) to assess the right ventricular (RV) myocardial mechanics by two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography (STE) in patients with an ischemic or non-ischemic etiology of end-stage heart failure (HF) and (2) to explore which RV index evaluated by 2D- and 3D-STE was the most powerful indicator for identifying the ischemic and non-ischemic etiologies of end-stage HF. METHODS: A total of 96 patients with left ventricular ejection fraction (LVEF) < 30% were enrolled in our study: 42 patients (mean age, 52 ± 10 years; 9.5% female) with ischemic cardiomyopathy and 54 patients (mean age, 46 ± 14 years; 16.7% female) with non-ischemic cardiomyopathy. A total of 45 healthy subjects (mean age, 46 ± 13 years; 24.4% female) served as controls. The longitudinal strain of the RV free wall (RVFWLS) was determined by both 2D- and 3D-STE. RESULTS: Compared to controls, patients with an ischemic or non-ischemic etiology of end-stage HF had lower 2D-RVFWLS, 3D-RVFWLS and RV ejection fraction (RVEF) values (P < 0.05). Patients with non-ischemic cardiomyopathies (NICMs) had significantly lower 3D-RVFWLS and RVEF values than in those with ischemic cardiomyopathies (ICMs), whereas 2D-RVFWLS and conventional RV function parameters did not differ between the two subgroups. RVEF was highly related to 3D-RVFWLS (r = 0.72, P < 0.001), modestly related to 2D-RVFWLS (r = 0.51, P < 0.001), and weakly related to conventional RV function indices (r = –0.26 to 0.46, P < 0.05). Receiver operating characteristic curve analysis revealed that the optimal 3D-RVFWLS cut-off value to distinguish NICM from ICM patients was –14.78% (area under the curve: 0.73, P < 0.001), while 2D-RVFWLS and conventional RV echocardiographic parameters did not. CONCLUSION: Our study demonstrated the superiority of 3D-RVFWLS over 2D-RVFWLS and conventional RV function indices in identifying the ischemic and non-ischemic etiologies of end-stage HF. These findings support the idea that 3D-RVFWLS may be a promising non-invasive imaging marker for distinguishing NICM from ICM.
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spelling pubmed-91744532022-06-09 Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure Tian, Fangyan Gu, Ying Zhang, Yanting Zhang, Bei Xie, Yuji Yu, Shaomei Zhu, Shuangshuang Sun, Wei Cheng, Shan Qian, Mingzu Lin, Yixia Wu, Wenqian Yang, Yali Lv, Qing Wang, Jing Zhang, Li Li, Yuman Xie, Mingxing Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: The aims of our study were (1) to assess the right ventricular (RV) myocardial mechanics by two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography (STE) in patients with an ischemic or non-ischemic etiology of end-stage heart failure (HF) and (2) to explore which RV index evaluated by 2D- and 3D-STE was the most powerful indicator for identifying the ischemic and non-ischemic etiologies of end-stage HF. METHODS: A total of 96 patients with left ventricular ejection fraction (LVEF) < 30% were enrolled in our study: 42 patients (mean age, 52 ± 10 years; 9.5% female) with ischemic cardiomyopathy and 54 patients (mean age, 46 ± 14 years; 16.7% female) with non-ischemic cardiomyopathy. A total of 45 healthy subjects (mean age, 46 ± 13 years; 24.4% female) served as controls. The longitudinal strain of the RV free wall (RVFWLS) was determined by both 2D- and 3D-STE. RESULTS: Compared to controls, patients with an ischemic or non-ischemic etiology of end-stage HF had lower 2D-RVFWLS, 3D-RVFWLS and RV ejection fraction (RVEF) values (P < 0.05). Patients with non-ischemic cardiomyopathies (NICMs) had significantly lower 3D-RVFWLS and RVEF values than in those with ischemic cardiomyopathies (ICMs), whereas 2D-RVFWLS and conventional RV function parameters did not differ between the two subgroups. RVEF was highly related to 3D-RVFWLS (r = 0.72, P < 0.001), modestly related to 2D-RVFWLS (r = 0.51, P < 0.001), and weakly related to conventional RV function indices (r = –0.26 to 0.46, P < 0.05). Receiver operating characteristic curve analysis revealed that the optimal 3D-RVFWLS cut-off value to distinguish NICM from ICM patients was –14.78% (area under the curve: 0.73, P < 0.001), while 2D-RVFWLS and conventional RV echocardiographic parameters did not. CONCLUSION: Our study demonstrated the superiority of 3D-RVFWLS over 2D-RVFWLS and conventional RV function indices in identifying the ischemic and non-ischemic etiologies of end-stage HF. These findings support the idea that 3D-RVFWLS may be a promising non-invasive imaging marker for distinguishing NICM from ICM. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174453/ /pubmed/35694662 http://dx.doi.org/10.3389/fcvm.2022.765191 Text en Copyright © 2022 Tian, Gu, Zhang, Zhang, Xie, Yu, Zhu, Sun, Cheng, Qian, Lin, Wu, Yang, Lv, Wang, Zhang, Li and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Tian, Fangyan
Gu, Ying
Zhang, Yanting
Zhang, Bei
Xie, Yuji
Yu, Shaomei
Zhu, Shuangshuang
Sun, Wei
Cheng, Shan
Qian, Mingzu
Lin, Yixia
Wu, Wenqian
Yang, Yali
Lv, Qing
Wang, Jing
Zhang, Li
Li, Yuman
Xie, Mingxing
Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure
title Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure
title_full Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure
title_fullStr Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure
title_full_unstemmed Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure
title_short Evaluation of Right Ventricular Myocardial Mechanics by 2- and 3-Dimensional Speckle-Tracking Echocardiography in Patients With an Ischemic or Non-ischemic Etiology of End-Stage Heart Failure
title_sort evaluation of right ventricular myocardial mechanics by 2- and 3-dimensional speckle-tracking echocardiography in patients with an ischemic or non-ischemic etiology of end-stage heart failure
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174453/
https://www.ncbi.nlm.nih.gov/pubmed/35694662
http://dx.doi.org/10.3389/fcvm.2022.765191
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