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Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey

The stria terminalis (ST) is a major bidirectional fiber tract anchored in the amygdala and bed nucleus (BNST). Extensive investigations in rodents report a complex arrangement of neurochemically diverse neurons within the ST, but fewer data are available for non-human primates. Given the functional...

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Autores principales: Sakharkar, Mitali, Rockland, Kathleen S., Duque, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174467/
https://www.ncbi.nlm.nih.gov/pubmed/35692258
http://dx.doi.org/10.3389/fnana.2022.891608
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author Sakharkar, Mitali
Rockland, Kathleen S.
Duque, Alvaro
author_facet Sakharkar, Mitali
Rockland, Kathleen S.
Duque, Alvaro
author_sort Sakharkar, Mitali
collection PubMed
description The stria terminalis (ST) is a major bidirectional fiber tract anchored in the amygdala and bed nucleus (BNST). Extensive investigations in rodents report a complex arrangement of neurochemically diverse neurons within the ST, but fewer data are available for non-human primates. Given the functional importance of the ST, we investigated its microarchitecture in one newborn, four infant, and two adult macaque brains, by parallel immunocytochemical series for cells or fibers. Main results are as follows: (1) The pan-neuronal marker NeuN shows scattered neurons and small neuronal clusters in both the dorsal and ventral ST, but more numerous dorsally; (2) smaller neuronal subpopulations are labeled by calretinin (CR), neuropeptide Y (NPY), calbindin (CB), and somatostatin (SOM), of which the CR + neurons are the most numerous; (3) the infant brains on average have more neurons in the ST than the adult brains, but across our sample, there is notable individual variability; and (4) fiber architectonics have a complex organization, which can be referenced to myelin-poor or myelin-dense zones. Myelin-poor zones coincide with concentrations of fibers positive for CB, CR, or tyrosine hydroxylase (TH). Neurons have been reported in other white matter domains (e.g., anterior commissure, corpus callosum, cingulum bundle, and subcortical white matter). Like these, at least some neurons within the ST may give rise to long-distance connections, and/or participate in more local functions, such as vascular regulation or axon guidance/maintenance.
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spelling pubmed-91744672022-06-09 Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey Sakharkar, Mitali Rockland, Kathleen S. Duque, Alvaro Front Neuroanat Neuroanatomy The stria terminalis (ST) is a major bidirectional fiber tract anchored in the amygdala and bed nucleus (BNST). Extensive investigations in rodents report a complex arrangement of neurochemically diverse neurons within the ST, but fewer data are available for non-human primates. Given the functional importance of the ST, we investigated its microarchitecture in one newborn, four infant, and two adult macaque brains, by parallel immunocytochemical series for cells or fibers. Main results are as follows: (1) The pan-neuronal marker NeuN shows scattered neurons and small neuronal clusters in both the dorsal and ventral ST, but more numerous dorsally; (2) smaller neuronal subpopulations are labeled by calretinin (CR), neuropeptide Y (NPY), calbindin (CB), and somatostatin (SOM), of which the CR + neurons are the most numerous; (3) the infant brains on average have more neurons in the ST than the adult brains, but across our sample, there is notable individual variability; and (4) fiber architectonics have a complex organization, which can be referenced to myelin-poor or myelin-dense zones. Myelin-poor zones coincide with concentrations of fibers positive for CB, CR, or tyrosine hydroxylase (TH). Neurons have been reported in other white matter domains (e.g., anterior commissure, corpus callosum, cingulum bundle, and subcortical white matter). Like these, at least some neurons within the ST may give rise to long-distance connections, and/or participate in more local functions, such as vascular regulation or axon guidance/maintenance. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174467/ /pubmed/35692258 http://dx.doi.org/10.3389/fnana.2022.891608 Text en Copyright © 2022 Sakharkar, Rockland and Duque. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroanatomy
Sakharkar, Mitali
Rockland, Kathleen S.
Duque, Alvaro
Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey
title Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey
title_full Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey
title_fullStr Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey
title_full_unstemmed Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey
title_short Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey
title_sort complex neurochemical microstructure of the stria terminalis in infant and adult macaque monkey
topic Neuroanatomy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174467/
https://www.ncbi.nlm.nih.gov/pubmed/35692258
http://dx.doi.org/10.3389/fnana.2022.891608
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