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Regulatory B cell repertoire defects predispose lung cancer patients to immune-related toxicity following checkpoint blockade
Checkpoint blockade with Pembrolizumab, has demonstrated durable clinical responses in advanced non-small cell lung cancer, however, treatment is offset by the development of high-grade immune related adverse events (irAEs) in some patients. Here, we show that in these patients a deficient Breg chec...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174492/ https://www.ncbi.nlm.nih.gov/pubmed/35672305 http://dx.doi.org/10.1038/s41467-022-30863-x |