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Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases
Between 2% and 6% of epithelial ovarian cancer (EOC) patients develop brain metastases (brain mets), which are incurable and invariably result in death. This poor outcome is associated with a lack of established guidelines for the detection and treatment of brain mets in EOC patients. In this study,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174542/ https://www.ncbi.nlm.nih.gov/pubmed/35692807 http://dx.doi.org/10.3389/fonc.2022.903806 |
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author | Pejovic, Tanja Abate, Pierre-Valérien Ma, Hongli Thiessen, Jaclyn Corless, Christopher L. Peterson, Abigail Allard-Chamard, Hugues Labrie, Marilyne |
author_facet | Pejovic, Tanja Abate, Pierre-Valérien Ma, Hongli Thiessen, Jaclyn Corless, Christopher L. Peterson, Abigail Allard-Chamard, Hugues Labrie, Marilyne |
author_sort | Pejovic, Tanja |
collection | PubMed |
description | Between 2% and 6% of epithelial ovarian cancer (EOC) patients develop brain metastases (brain mets), which are incurable and invariably result in death. This poor outcome is associated with a lack of established guidelines for the detection and treatment of brain mets in EOC patients. In this study, we characterize an unusual case of low-grade serous ovarian carcinoma (LGSOC) that metastasized to the brain. Using a spatially oriented single-cell proteomics platform, we compared sequential biopsies of a primary tumor with a peritoneal recurrence and brain mets. We identified several targetable oncogenic pathways and immunosuppressive mechanisms that are amplified in the brain mets and could be involved in the progression of LGSOC to the brain. Furthermore, we were able to identify cell populations that are shared between the primary tumor and the brain mets, suggesting that cells that have a propensity for metastasis to the brain could be identified early during the course of disease. Taken together, our findings further a path for personalized therapeutic decisions in LGSOC. |
format | Online Article Text |
id | pubmed-9174542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91745422022-06-09 Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases Pejovic, Tanja Abate, Pierre-Valérien Ma, Hongli Thiessen, Jaclyn Corless, Christopher L. Peterson, Abigail Allard-Chamard, Hugues Labrie, Marilyne Front Oncol Oncology Between 2% and 6% of epithelial ovarian cancer (EOC) patients develop brain metastases (brain mets), which are incurable and invariably result in death. This poor outcome is associated with a lack of established guidelines for the detection and treatment of brain mets in EOC patients. In this study, we characterize an unusual case of low-grade serous ovarian carcinoma (LGSOC) that metastasized to the brain. Using a spatially oriented single-cell proteomics platform, we compared sequential biopsies of a primary tumor with a peritoneal recurrence and brain mets. We identified several targetable oncogenic pathways and immunosuppressive mechanisms that are amplified in the brain mets and could be involved in the progression of LGSOC to the brain. Furthermore, we were able to identify cell populations that are shared between the primary tumor and the brain mets, suggesting that cells that have a propensity for metastasis to the brain could be identified early during the course of disease. Taken together, our findings further a path for personalized therapeutic decisions in LGSOC. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174542/ /pubmed/35692807 http://dx.doi.org/10.3389/fonc.2022.903806 Text en Copyright © 2022 Pejovic, Abate, Ma, Thiessen, Corless, Peterson, Allard-Chamard and Labrie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Pejovic, Tanja Abate, Pierre-Valérien Ma, Hongli Thiessen, Jaclyn Corless, Christopher L. Peterson, Abigail Allard-Chamard, Hugues Labrie, Marilyne Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases |
title | Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases |
title_full | Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases |
title_fullStr | Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases |
title_full_unstemmed | Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases |
title_short | Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases |
title_sort | single-cell proteomics analysis of recurrent low-grade serous ovarian carcinoma and associated brain metastases |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174542/ https://www.ncbi.nlm.nih.gov/pubmed/35692807 http://dx.doi.org/10.3389/fonc.2022.903806 |
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