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Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress

Oxidative stress and excessive inflammatory responses are the two critical mechanisms of hepatic ischemia-reperfusion injury (HIRI) encountered in many clinical settings, including following hepatectomy and liver transplantation. Effective anti-inflammatory and anti-oxidative pharmacological interve...

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Autores principales: Huang, Yongxin, Xu, Qinyuan, Zhang, Jiang, Yin, Yanze, Pan, Yixiao, Zheng, Yuanyi, Cai, Xiaojun, Xia, Qiang, He, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174572/
https://www.ncbi.nlm.nih.gov/pubmed/35693813
http://dx.doi.org/10.3389/fimmu.2022.891351
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author Huang, Yongxin
Xu, Qinyuan
Zhang, Jiang
Yin, Yanze
Pan, Yixiao
Zheng, Yuanyi
Cai, Xiaojun
Xia, Qiang
He, Kang
author_facet Huang, Yongxin
Xu, Qinyuan
Zhang, Jiang
Yin, Yanze
Pan, Yixiao
Zheng, Yuanyi
Cai, Xiaojun
Xia, Qiang
He, Kang
author_sort Huang, Yongxin
collection PubMed
description Oxidative stress and excessive inflammatory responses are the two critical mechanisms of hepatic ischemia-reperfusion injury (HIRI) encountered in many clinical settings, including following hepatectomy and liver transplantation. Effective anti-inflammatory and anti-oxidative pharmacological interventions are urgently needed to counter HIRI. The present study showed that a biocompatible Prussian blue (PB) scavenger with reactive oxygen species (ROS) scavenging and anti-inflammatory properties might be used a promising treatment for HIRI. Following intravenous administration, PB scavenger was mainly distributed in the liver, where it showed excellent ability to alleviate apoptosis, tissue injury and organ dysfunction after HIRI. PB scavenger was found to protect liver tissue by scavenging ROS, reducing neutrophil infiltration and promoting macrophage M2 polarization. In addition, PB scavenger significantly reduced oxidative stress in primary hepatocytes, restoring cell viability under oxidative stress condition. PB scavenger effectively reduced lipopolysaccharide-stimulated inflammation in RAW 264.7 cells. These findings indicate that PB scavenger may be a potential therapeutic agent for the treatment of HIRI, providing an alternative treatment for ROS-associated and inflammatory liver diseases.
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spelling pubmed-91745722022-06-09 Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress Huang, Yongxin Xu, Qinyuan Zhang, Jiang Yin, Yanze Pan, Yixiao Zheng, Yuanyi Cai, Xiaojun Xia, Qiang He, Kang Front Immunol Immunology Oxidative stress and excessive inflammatory responses are the two critical mechanisms of hepatic ischemia-reperfusion injury (HIRI) encountered in many clinical settings, including following hepatectomy and liver transplantation. Effective anti-inflammatory and anti-oxidative pharmacological interventions are urgently needed to counter HIRI. The present study showed that a biocompatible Prussian blue (PB) scavenger with reactive oxygen species (ROS) scavenging and anti-inflammatory properties might be used a promising treatment for HIRI. Following intravenous administration, PB scavenger was mainly distributed in the liver, where it showed excellent ability to alleviate apoptosis, tissue injury and organ dysfunction after HIRI. PB scavenger was found to protect liver tissue by scavenging ROS, reducing neutrophil infiltration and promoting macrophage M2 polarization. In addition, PB scavenger significantly reduced oxidative stress in primary hepatocytes, restoring cell viability under oxidative stress condition. PB scavenger effectively reduced lipopolysaccharide-stimulated inflammation in RAW 264.7 cells. These findings indicate that PB scavenger may be a potential therapeutic agent for the treatment of HIRI, providing an alternative treatment for ROS-associated and inflammatory liver diseases. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174572/ /pubmed/35693813 http://dx.doi.org/10.3389/fimmu.2022.891351 Text en Copyright © 2022 Huang, Xu, Zhang, Yin, Pan, Zheng, Cai, Xia and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Yongxin
Xu, Qinyuan
Zhang, Jiang
Yin, Yanze
Pan, Yixiao
Zheng, Yuanyi
Cai, Xiaojun
Xia, Qiang
He, Kang
Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
title Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
title_full Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
title_fullStr Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
title_full_unstemmed Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
title_short Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress
title_sort prussian blue scavenger ameliorates hepatic ischemia-reperfusion injury by inhibiting inflammation and reducing oxidative stress
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174572/
https://www.ncbi.nlm.nih.gov/pubmed/35693813
http://dx.doi.org/10.3389/fimmu.2022.891351
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