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Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults

Inflammatory myofibroblastic tumour (IMT) is an unusual myofibroblastic spindle cell neoplasm that is rarely discovered in the airway of adults. Previously, it was regarded as a reactive lesion and was infamously known as inflammatory pseudotumour before recent insights revealed that significant maj...

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Autores principales: Lourdesamy Anthony, Albert Iruthiaraj, Satnam Singh, Taranjit Kaur, Ng, Khai Lip, Abdul Rahaman, Jamalul Azizi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174595/
https://www.ncbi.nlm.nih.gov/pubmed/35702693
http://dx.doi.org/10.1002/rcr2.984
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author Lourdesamy Anthony, Albert Iruthiaraj
Satnam Singh, Taranjit Kaur
Ng, Khai Lip
Abdul Rahaman, Jamalul Azizi
author_facet Lourdesamy Anthony, Albert Iruthiaraj
Satnam Singh, Taranjit Kaur
Ng, Khai Lip
Abdul Rahaman, Jamalul Azizi
author_sort Lourdesamy Anthony, Albert Iruthiaraj
collection PubMed
description Inflammatory myofibroblastic tumour (IMT) is an unusual myofibroblastic spindle cell neoplasm that is rarely discovered in the airway of adults. Previously, it was regarded as a reactive lesion and was infamously known as inflammatory pseudotumour before recent insights revealed that significant majority of cases harboured neoplastic genes. Diagnosis is difficult as clinical presentation and imaging findings are non‐specific. Diagnosis and a favourable prognosis require the complete resection of the tumour. Detection of the anaplastic lymphoma kinase expression via immunohistochemistry expedites diagnosis. We report a young adult with an endotracheal mass occluding the central airway. The patient successfully underwent bronchoscopic resection using interventional techniques. IMT was diagnosed. No recurrence was seen after a year of surveillance. Due to the rarity of the disease, the recurrence rates for large airway disease is unknown. Recurrence rates for pulmonary lesions is reported to be lower compared to extrapulmonary IMTs and recurrence is unlikely if compete surgical excision is achieved.
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spelling pubmed-91745952022-06-13 Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults Lourdesamy Anthony, Albert Iruthiaraj Satnam Singh, Taranjit Kaur Ng, Khai Lip Abdul Rahaman, Jamalul Azizi Respirol Case Rep Case Reports Inflammatory myofibroblastic tumour (IMT) is an unusual myofibroblastic spindle cell neoplasm that is rarely discovered in the airway of adults. Previously, it was regarded as a reactive lesion and was infamously known as inflammatory pseudotumour before recent insights revealed that significant majority of cases harboured neoplastic genes. Diagnosis is difficult as clinical presentation and imaging findings are non‐specific. Diagnosis and a favourable prognosis require the complete resection of the tumour. Detection of the anaplastic lymphoma kinase expression via immunohistochemistry expedites diagnosis. We report a young adult with an endotracheal mass occluding the central airway. The patient successfully underwent bronchoscopic resection using interventional techniques. IMT was diagnosed. No recurrence was seen after a year of surveillance. Due to the rarity of the disease, the recurrence rates for large airway disease is unknown. Recurrence rates for pulmonary lesions is reported to be lower compared to extrapulmonary IMTs and recurrence is unlikely if compete surgical excision is achieved. John Wiley & Sons, Ltd 2022-06-07 /pmc/articles/PMC9174595/ /pubmed/35702693 http://dx.doi.org/10.1002/rcr2.984 Text en © 2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Lourdesamy Anthony, Albert Iruthiaraj
Satnam Singh, Taranjit Kaur
Ng, Khai Lip
Abdul Rahaman, Jamalul Azizi
Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
title Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
title_full Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
title_fullStr Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
title_full_unstemmed Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
title_short Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults
title_sort endotracheal inflammatory myofibroblastic tumour: a rare cause of central airway occlusion in adults
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174595/
https://www.ncbi.nlm.nih.gov/pubmed/35702693
http://dx.doi.org/10.1002/rcr2.984
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