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Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates

Spexin (SPX) and galanin (GAL) are two neuropeptides that are phylogenetically related and have descended from a common ancestral gene. Considerable attention has been given to these two multifunctional neuropeptides because they share GAL receptors 1,2, and 3. Since GAL and SPX-synthesizing neurons...

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Autores principales: Mohd Zahir, Izzati, Ogawa, Satoshi, Dominic, Nisha Angela, Soga, Tomoko, Parhar, Ishwar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174643/
https://www.ncbi.nlm.nih.gov/pubmed/35692389
http://dx.doi.org/10.3389/fendo.2022.882772
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author Mohd Zahir, Izzati
Ogawa, Satoshi
Dominic, Nisha Angela
Soga, Tomoko
Parhar, Ishwar S.
author_facet Mohd Zahir, Izzati
Ogawa, Satoshi
Dominic, Nisha Angela
Soga, Tomoko
Parhar, Ishwar S.
author_sort Mohd Zahir, Izzati
collection PubMed
description Spexin (SPX) and galanin (GAL) are two neuropeptides that are phylogenetically related and have descended from a common ancestral gene. Considerable attention has been given to these two multifunctional neuropeptides because they share GAL receptors 1,2, and 3. Since GAL and SPX-synthesizing neurons have been detected in several brain areas, therefore, it can be speculated that SPX and GAL are involved in various neurophysiological functions. Several studies have shown the functions of these two neuropeptides in energy regulation, reproduction, and response to stress. SPX acts as a satiety factor to suppress food intake, while GAL has the opposite effect as an orexigenic factor. There is evidence that SPX acts as an inhibitor of reproductive functions by suppressing gonadotropin release, while GAL modulates the activity of gonadotropin-releasing hormone (GnRH) neurons in the brain and gonadotropic cells in the pituitary. SPX and GAL are responsive to stress. Furthermore, SPX can act as an anxiolytic factor, while GAL exerts anti-depressant and pro-depressive effects depending on the receptor it binds. This review describes evidence supporting the central roles of SPX and GAL neuropeptides in energy balance, reproduction, stress, and social behaviors, with a particular focus on non-mammalian vertebrate systems.
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spelling pubmed-91746432022-06-09 Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates Mohd Zahir, Izzati Ogawa, Satoshi Dominic, Nisha Angela Soga, Tomoko Parhar, Ishwar S. Front Endocrinol (Lausanne) Endocrinology Spexin (SPX) and galanin (GAL) are two neuropeptides that are phylogenetically related and have descended from a common ancestral gene. Considerable attention has been given to these two multifunctional neuropeptides because they share GAL receptors 1,2, and 3. Since GAL and SPX-synthesizing neurons have been detected in several brain areas, therefore, it can be speculated that SPX and GAL are involved in various neurophysiological functions. Several studies have shown the functions of these two neuropeptides in energy regulation, reproduction, and response to stress. SPX acts as a satiety factor to suppress food intake, while GAL has the opposite effect as an orexigenic factor. There is evidence that SPX acts as an inhibitor of reproductive functions by suppressing gonadotropin release, while GAL modulates the activity of gonadotropin-releasing hormone (GnRH) neurons in the brain and gonadotropic cells in the pituitary. SPX and GAL are responsive to stress. Furthermore, SPX can act as an anxiolytic factor, while GAL exerts anti-depressant and pro-depressive effects depending on the receptor it binds. This review describes evidence supporting the central roles of SPX and GAL neuropeptides in energy balance, reproduction, stress, and social behaviors, with a particular focus on non-mammalian vertebrate systems. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174643/ /pubmed/35692389 http://dx.doi.org/10.3389/fendo.2022.882772 Text en Copyright © 2022 Mohd Zahir, Ogawa, Dominic, Soga and Parhar https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Mohd Zahir, Izzati
Ogawa, Satoshi
Dominic, Nisha Angela
Soga, Tomoko
Parhar, Ishwar S.
Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
title Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
title_full Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
title_fullStr Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
title_full_unstemmed Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
title_short Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates
title_sort spexin and galanin in metabolic functions and social behaviors with a focus on non-mammalian vertebrates
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174643/
https://www.ncbi.nlm.nih.gov/pubmed/35692389
http://dx.doi.org/10.3389/fendo.2022.882772
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