Cargando…
Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee
A 30-year-old woman presented to our hospital with an 11-year history of gradually enlarging masses around the left knee and 2-year history of progressively worsening bone pain. Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome caused by phosphaturic mesenchymal tumors (PMTs) was susp...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174667/ https://www.ncbi.nlm.nih.gov/pubmed/35693311 http://dx.doi.org/10.3389/fsurg.2022.746623 |
_version_ | 1784722288751411200 |
---|---|
author | Sun, Juan Zhou, Xi Xia, Weibo Wu, Huanwen Liu, Shuzhong Wang, Huizhen Liu, Yong |
author_facet | Sun, Juan Zhou, Xi Xia, Weibo Wu, Huanwen Liu, Shuzhong Wang, Huizhen Liu, Yong |
author_sort | Sun, Juan |
collection | PubMed |
description | A 30-year-old woman presented to our hospital with an 11-year history of gradually enlarging masses around the left knee and 2-year history of progressively worsening bone pain. Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome caused by phosphaturic mesenchymal tumors (PMTs) was suspected, but the postoperative pathology of her two operations was both reported as tenosynovial giant cell tumor (TGCT), making its diagnosis confusing. The possibility of hypophosphatemia, insufficient blood supply, innervation of the left lower limbs, as well as the unclear pathology, make it unreasonable to perform tumor-type knee prosthesis replacement directly. Finally, we placed static polymethylmethacrylate (PMMA) spacer at first, then when the concentration of blood phosphorus level rose to the normal range, the pathology was confirmed to be TIO, the blood supply and innervation was satisfying, tumor-type knee prosthesis replacement was performed. She was discharged post operative day 15 after the prothesis implantation without incident. One and a half years after her surgery, the concentration of blood phosphorus was still in the normal range, the symptom of systemic bone pain had improved significantly, the prosthesis was still in a good position and no recurrence was caught. |
format | Online Article Text |
id | pubmed-9174667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91746672022-06-09 Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee Sun, Juan Zhou, Xi Xia, Weibo Wu, Huanwen Liu, Shuzhong Wang, Huizhen Liu, Yong Front Surg Surgery A 30-year-old woman presented to our hospital with an 11-year history of gradually enlarging masses around the left knee and 2-year history of progressively worsening bone pain. Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome caused by phosphaturic mesenchymal tumors (PMTs) was suspected, but the postoperative pathology of her two operations was both reported as tenosynovial giant cell tumor (TGCT), making its diagnosis confusing. The possibility of hypophosphatemia, insufficient blood supply, innervation of the left lower limbs, as well as the unclear pathology, make it unreasonable to perform tumor-type knee prosthesis replacement directly. Finally, we placed static polymethylmethacrylate (PMMA) spacer at first, then when the concentration of blood phosphorus level rose to the normal range, the pathology was confirmed to be TIO, the blood supply and innervation was satisfying, tumor-type knee prosthesis replacement was performed. She was discharged post operative day 15 after the prothesis implantation without incident. One and a half years after her surgery, the concentration of blood phosphorus was still in the normal range, the symptom of systemic bone pain had improved significantly, the prosthesis was still in a good position and no recurrence was caught. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174667/ /pubmed/35693311 http://dx.doi.org/10.3389/fsurg.2022.746623 Text en Copyright © 2022 Sun, Zhou, Xia, Wu, Liu, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Sun, Juan Zhou, Xi Xia, Weibo Wu, Huanwen Liu, Shuzhong Wang, Huizhen Liu, Yong Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee |
title | Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee |
title_full | Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee |
title_fullStr | Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee |
title_full_unstemmed | Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee |
title_short | Unusual Presentation and Surgical Treatment of a Phosphaturic Mesenchymal Tumor in a Knee |
title_sort | unusual presentation and surgical treatment of a phosphaturic mesenchymal tumor in a knee |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174667/ https://www.ncbi.nlm.nih.gov/pubmed/35693311 http://dx.doi.org/10.3389/fsurg.2022.746623 |
work_keys_str_mv | AT sunjuan unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee AT zhouxi unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee AT xiaweibo unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee AT wuhuanwen unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee AT liushuzhong unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee AT wanghuizhen unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee AT liuyong unusualpresentationandsurgicaltreatmentofaphosphaturicmesenchymaltumorinaknee |