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Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing

Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC lateral membrane, which imparts piezoelectric properties to the cell me...

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Detalles Bibliográficos
Autor principal: Rabbitt, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174718/
https://www.ncbi.nlm.nih.gov/pubmed/35673856
http://dx.doi.org/10.1098/rsif.2022.0139
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author Rabbitt, Richard D.
author_facet Rabbitt, Richard D.
author_sort Rabbitt, Richard D.
collection PubMed
description Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC lateral membrane, which imparts piezoelectric properties to the cell membrane. In the present report, electrical power consumption and mechanical power output of the OHC membrane–motor complex are determined using previously published voltage-clamp data from isolated OHCs and membrane patches. Results reveal that power output peaks at a best frequency much higher than implied by the low-pass character of nonlinear capacitance, and much higher than the whole-cell resistive–capacitive corner frequency. High frequency power output is enabled by a −90° shift in the phase of electrical charge displacement in the membrane, manifested electrically as emergence of imaginary-valued nonlinear capacitance.
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spelling pubmed-91747182022-06-08 Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing Rabbitt, Richard D. J R Soc Interface Life Sciences–Physics interface Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC lateral membrane, which imparts piezoelectric properties to the cell membrane. In the present report, electrical power consumption and mechanical power output of the OHC membrane–motor complex are determined using previously published voltage-clamp data from isolated OHCs and membrane patches. Results reveal that power output peaks at a best frequency much higher than implied by the low-pass character of nonlinear capacitance, and much higher than the whole-cell resistive–capacitive corner frequency. High frequency power output is enabled by a −90° shift in the phase of electrical charge displacement in the membrane, manifested electrically as emergence of imaginary-valued nonlinear capacitance. The Royal Society 2022-06-08 /pmc/articles/PMC9174718/ /pubmed/35673856 http://dx.doi.org/10.1098/rsif.2022.0139 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Physics interface
Rabbitt, Richard D.
Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
title Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
title_full Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
title_fullStr Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
title_full_unstemmed Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
title_short Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
title_sort analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing
topic Life Sciences–Physics interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174718/
https://www.ncbi.nlm.nih.gov/pubmed/35673856
http://dx.doi.org/10.1098/rsif.2022.0139
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