Cargando…
Past, Present and Future: The Relationship Between Circular RNA and Immunity
The immune system has evolved since the birth of humans. However, immune-related diseases have not yet been overcome due to the lack of expected indicators and targeting specificity of current medical technology, subjecting patients to very uncomfortable physical and mental experiences and high medi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174805/ https://www.ncbi.nlm.nih.gov/pubmed/35693804 http://dx.doi.org/10.3389/fimmu.2022.894707 |
_version_ | 1784722320429940736 |
---|---|
author | Gu, Junjie Su, Chongying Huang, Fei Zhao, Yuwei Li, Jing |
author_facet | Gu, Junjie Su, Chongying Huang, Fei Zhao, Yuwei Li, Jing |
author_sort | Gu, Junjie |
collection | PubMed |
description | The immune system has evolved since the birth of humans. However, immune-related diseases have not yet been overcome due to the lack of expected indicators and targeting specificity of current medical technology, subjecting patients to very uncomfortable physical and mental experiences and high medical costs. Therefore, the requirements for treatments with higher specificity and indicative ability are raised. Fortunately, the discovery of and continuous research investigating circular RNAs (circRNAs) represent a promising method among numerous methods. Although circRNAs wear regarded as metabolic wastes when discovered, as a type of noncoding RNA (ncRNA) with a ring structure and wide distribution range in the human body, circRNAs shine brilliantly in medical research by virtue of their special nature and structure-determined functions, such as high stability, wide distribution, high detection sensitivity, acceptable reproducibility and individual differences. Based on research investigating the role of circRNAs in immunity, we systematically discuss the hotspots of the roles of circRNAs in immune-related diseases, including expression profile analyses, potential biomarker research, ncRNA axis/network construction, impacts on phenotypes, therapeutic target seeking, maintenance of nucleic acid stability and protein binding research. In addition, we summarize the current situation of and problems associated with circRNAs in immune research, highlight the applications and prospects of circRNAs in the treatment of immune-related diseases, and provide new insight into future directions and new strategies for laboratory research and clinical applications. |
format | Online Article Text |
id | pubmed-9174805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91748052022-06-09 Past, Present and Future: The Relationship Between Circular RNA and Immunity Gu, Junjie Su, Chongying Huang, Fei Zhao, Yuwei Li, Jing Front Immunol Immunology The immune system has evolved since the birth of humans. However, immune-related diseases have not yet been overcome due to the lack of expected indicators and targeting specificity of current medical technology, subjecting patients to very uncomfortable physical and mental experiences and high medical costs. Therefore, the requirements for treatments with higher specificity and indicative ability are raised. Fortunately, the discovery of and continuous research investigating circular RNAs (circRNAs) represent a promising method among numerous methods. Although circRNAs wear regarded as metabolic wastes when discovered, as a type of noncoding RNA (ncRNA) with a ring structure and wide distribution range in the human body, circRNAs shine brilliantly in medical research by virtue of their special nature and structure-determined functions, such as high stability, wide distribution, high detection sensitivity, acceptable reproducibility and individual differences. Based on research investigating the role of circRNAs in immunity, we systematically discuss the hotspots of the roles of circRNAs in immune-related diseases, including expression profile analyses, potential biomarker research, ncRNA axis/network construction, impacts on phenotypes, therapeutic target seeking, maintenance of nucleic acid stability and protein binding research. In addition, we summarize the current situation of and problems associated with circRNAs in immune research, highlight the applications and prospects of circRNAs in the treatment of immune-related diseases, and provide new insight into future directions and new strategies for laboratory research and clinical applications. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174805/ /pubmed/35693804 http://dx.doi.org/10.3389/fimmu.2022.894707 Text en Copyright © 2022 Gu, Su, Huang, Zhao and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gu, Junjie Su, Chongying Huang, Fei Zhao, Yuwei Li, Jing Past, Present and Future: The Relationship Between Circular RNA and Immunity |
title | Past, Present and Future: The Relationship Between Circular RNA and Immunity |
title_full | Past, Present and Future: The Relationship Between Circular RNA and Immunity |
title_fullStr | Past, Present and Future: The Relationship Between Circular RNA and Immunity |
title_full_unstemmed | Past, Present and Future: The Relationship Between Circular RNA and Immunity |
title_short | Past, Present and Future: The Relationship Between Circular RNA and Immunity |
title_sort | past, present and future: the relationship between circular rna and immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174805/ https://www.ncbi.nlm.nih.gov/pubmed/35693804 http://dx.doi.org/10.3389/fimmu.2022.894707 |
work_keys_str_mv | AT gujunjie pastpresentandfuturetherelationshipbetweencircularrnaandimmunity AT suchongying pastpresentandfuturetherelationshipbetweencircularrnaandimmunity AT huangfei pastpresentandfuturetherelationshipbetweencircularrnaandimmunity AT zhaoyuwei pastpresentandfuturetherelationshipbetweencircularrnaandimmunity AT lijing pastpresentandfuturetherelationshipbetweencircularrnaandimmunity |