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Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

BACKGROUND: Long-term prognosis of WHO grade II, isocitrate dehydrogenase (IDH)-mutated low-grade glioma (LGG) is poor due to high risks of recurrence and malignant transformation into high-grade glioma. Immunotherapy strategies are attractive given the relatively intact immune system of patients wi...

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Detalles Bibliográficos
Autores principales:	Chuntova, Pavlina, Yamamichi, Akane, Chen, Tiffany, Narayanaswamy, Rohini, Ronseaux, Sebastien, Hudson, Christine, Tron, Adriana E, Hyer, Marc L, Montoya, Megan, Mende, Abigail L, Nejo, Takahide, Downey, Kira M, Diebold, David, Lu, Min, Nicolay, Brandon, Okada, Hideho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174833/ https://www.ncbi.nlm.nih.gov/pubmed/35606087 http://dx.doi.org/10.1136/jitc-2022-004644

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