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Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174858/ https://www.ncbi.nlm.nih.gov/pubmed/35711841 http://dx.doi.org/10.7150/jca.71619 |
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author | Shao, Gaoxuan Qian, Yufan Lu, Lu Liu, Ying Wu, Tao Ji, Guang Xu, Hanchen |
author_facet | Shao, Gaoxuan Qian, Yufan Lu, Lu Liu, Ying Wu, Tao Ji, Guang Xu, Hanchen |
author_sort | Shao, Gaoxuan |
collection | PubMed |
description | Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasis. Lysophosphatidylcholine acyltransferase 3 (LPCAT3, MBOAT5) is a member of the LPCAT family that primarily regulates the levels of arachidonic PC species. LPCAT3 is regulated by the liver X receptor, which plays an important role in lipoprotein production in the liver and small intestine. Increasing lines of research have demonstrated that LPCAT3 plays important roles in the occurrence and development of many diseases, such as atherosclerosis, intestinal tumors, and nonalcoholic steatohepatitis (NASH). The development of many diseases has been linked to the proinflammatory effects of LPCAT3. This review focuses on the current knowledge of LPCAT3, including its function and mechanism in different diseases. We aim to provide a comprehensive and in-depth understanding of LPCAT3 and to provide new ideas for the treatment of some diseases. |
format | Online Article Text |
id | pubmed-9174858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-91748582022-06-15 Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer Shao, Gaoxuan Qian, Yufan Lu, Lu Liu, Ying Wu, Tao Ji, Guang Xu, Hanchen J Cancer Review Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasis. Lysophosphatidylcholine acyltransferase 3 (LPCAT3, MBOAT5) is a member of the LPCAT family that primarily regulates the levels of arachidonic PC species. LPCAT3 is regulated by the liver X receptor, which plays an important role in lipoprotein production in the liver and small intestine. Increasing lines of research have demonstrated that LPCAT3 plays important roles in the occurrence and development of many diseases, such as atherosclerosis, intestinal tumors, and nonalcoholic steatohepatitis (NASH). The development of many diseases has been linked to the proinflammatory effects of LPCAT3. This review focuses on the current knowledge of LPCAT3, including its function and mechanism in different diseases. We aim to provide a comprehensive and in-depth understanding of LPCAT3 and to provide new ideas for the treatment of some diseases. Ivyspring International Publisher 2022-05-01 /pmc/articles/PMC9174858/ /pubmed/35711841 http://dx.doi.org/10.7150/jca.71619 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Shao, Gaoxuan Qian, Yufan Lu, Lu Liu, Ying Wu, Tao Ji, Guang Xu, Hanchen Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer |
title | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer |
title_full | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer |
title_fullStr | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer |
title_full_unstemmed | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer |
title_short | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer |
title_sort | research progress in the role and mechanism of lpcat3 in metabolic related diseases and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174858/ https://www.ncbi.nlm.nih.gov/pubmed/35711841 http://dx.doi.org/10.7150/jca.71619 |
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