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Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer

Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasi...

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Autores principales: Shao, Gaoxuan, Qian, Yufan, Lu, Lu, Liu, Ying, Wu, Tao, Ji, Guang, Xu, Hanchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174858/
https://www.ncbi.nlm.nih.gov/pubmed/35711841
http://dx.doi.org/10.7150/jca.71619
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author Shao, Gaoxuan
Qian, Yufan
Lu, Lu
Liu, Ying
Wu, Tao
Ji, Guang
Xu, Hanchen
author_facet Shao, Gaoxuan
Qian, Yufan
Lu, Lu
Liu, Ying
Wu, Tao
Ji, Guang
Xu, Hanchen
author_sort Shao, Gaoxuan
collection PubMed
description Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasis. Lysophosphatidylcholine acyltransferase 3 (LPCAT3, MBOAT5) is a member of the LPCAT family that primarily regulates the levels of arachidonic PC species. LPCAT3 is regulated by the liver X receptor, which plays an important role in lipoprotein production in the liver and small intestine. Increasing lines of research have demonstrated that LPCAT3 plays important roles in the occurrence and development of many diseases, such as atherosclerosis, intestinal tumors, and nonalcoholic steatohepatitis (NASH). The development of many diseases has been linked to the proinflammatory effects of LPCAT3. This review focuses on the current knowledge of LPCAT3, including its function and mechanism in different diseases. We aim to provide a comprehensive and in-depth understanding of LPCAT3 and to provide new ideas for the treatment of some diseases.
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spelling pubmed-91748582022-06-15 Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer Shao, Gaoxuan Qian, Yufan Lu, Lu Liu, Ying Wu, Tao Ji, Guang Xu, Hanchen J Cancer Review Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasis. Lysophosphatidylcholine acyltransferase 3 (LPCAT3, MBOAT5) is a member of the LPCAT family that primarily regulates the levels of arachidonic PC species. LPCAT3 is regulated by the liver X receptor, which plays an important role in lipoprotein production in the liver and small intestine. Increasing lines of research have demonstrated that LPCAT3 plays important roles in the occurrence and development of many diseases, such as atherosclerosis, intestinal tumors, and nonalcoholic steatohepatitis (NASH). The development of many diseases has been linked to the proinflammatory effects of LPCAT3. This review focuses on the current knowledge of LPCAT3, including its function and mechanism in different diseases. We aim to provide a comprehensive and in-depth understanding of LPCAT3 and to provide new ideas for the treatment of some diseases. Ivyspring International Publisher 2022-05-01 /pmc/articles/PMC9174858/ /pubmed/35711841 http://dx.doi.org/10.7150/jca.71619 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Shao, Gaoxuan
Qian, Yufan
Lu, Lu
Liu, Ying
Wu, Tao
Ji, Guang
Xu, Hanchen
Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
title Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
title_full Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
title_fullStr Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
title_full_unstemmed Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
title_short Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer
title_sort research progress in the role and mechanism of lpcat3 in metabolic related diseases and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174858/
https://www.ncbi.nlm.nih.gov/pubmed/35711841
http://dx.doi.org/10.7150/jca.71619
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