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GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network

Pancreatic adenocarcinoma (PAAD) is a digestive tumor with extremely high malignancy. Previous studies have reported that Glucose transporter 1 (GLUT1) contributes to the aggressive tumor progression in various cancer types and indicates an unfavorable prognosis. However, the function of GLUT1 in PA...

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Autores principales: Li, Fengjiao, He, Chong, Yao, Hanming, Liang, Weiling, Ye, Xijiu, Ruan, Jianmin, Lin, Lijun, Zou, Jinmao, Zhou, Shurui, Huang, Yuzhou, Li, Yaqing, Chen, Shaojie, Huang, Kaihong, Lian, Guoda, Chen, Shangxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174867/
https://www.ncbi.nlm.nih.gov/pubmed/35711842
http://dx.doi.org/10.7150/jca.72161
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author Li, Fengjiao
He, Chong
Yao, Hanming
Liang, Weiling
Ye, Xijiu
Ruan, Jianmin
Lin, Lijun
Zou, Jinmao
Zhou, Shurui
Huang, Yuzhou
Li, Yaqing
Chen, Shaojie
Huang, Kaihong
Lian, Guoda
Chen, Shangxiang
author_facet Li, Fengjiao
He, Chong
Yao, Hanming
Liang, Weiling
Ye, Xijiu
Ruan, Jianmin
Lin, Lijun
Zou, Jinmao
Zhou, Shurui
Huang, Yuzhou
Li, Yaqing
Chen, Shaojie
Huang, Kaihong
Lian, Guoda
Chen, Shangxiang
author_sort Li, Fengjiao
collection PubMed
description Pancreatic adenocarcinoma (PAAD) is a digestive tumor with extremely high malignancy. Previous studies have reported that Glucose transporter 1 (GLUT1) contributes to the aggressive tumor progression in various cancer types and indicates an unfavorable prognosis. However, the function of GLUT1 in PAAD remains largely unclear. Through pan-cancer analysis of GLUT1 expression, GLUT1 expression was significantly higher in several cancer types including PAAD. Survival analysis based on the GLUT1 expression showed that GLUT1 could serve as a predictor of poor prognosis. We further predicted and screened the candidate non-coding RNAs (ncRNAs) upstream of the GLUT1 mRNA through correlation analysis, and found that the CASC19/miR-140-5p axis contributing to the regulation of GLUT1 expression. Our study suggested a link exists between GLUT1 expression and selected immunity-related indicators. Subsequent analysis revealed overexpression of GLUT1 in pancreatic cancer specimens and patients with highly expressed GLUT1 expression had worse prognosis. Based on the significantly different expression of GLUT1, the possibility that GLUT1 participated in tumor progression was identified. Using online public databases, genes co-expressed with GLUT1 were screened and enriched to metastasis-related pathways by enrichment analysis. Additionally, functional assays verified that GLUT1 could function in the metastatic process of PAAD cancer cells. Therefore, we proposed that GLUT1 might serve as a role in tumor immunity and tumor metastasis, and was expected to be a prognostic factor in PAAD.
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spelling pubmed-91748672022-06-15 GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network Li, Fengjiao He, Chong Yao, Hanming Liang, Weiling Ye, Xijiu Ruan, Jianmin Lin, Lijun Zou, Jinmao Zhou, Shurui Huang, Yuzhou Li, Yaqing Chen, Shaojie Huang, Kaihong Lian, Guoda Chen, Shangxiang J Cancer Research Paper Pancreatic adenocarcinoma (PAAD) is a digestive tumor with extremely high malignancy. Previous studies have reported that Glucose transporter 1 (GLUT1) contributes to the aggressive tumor progression in various cancer types and indicates an unfavorable prognosis. However, the function of GLUT1 in PAAD remains largely unclear. Through pan-cancer analysis of GLUT1 expression, GLUT1 expression was significantly higher in several cancer types including PAAD. Survival analysis based on the GLUT1 expression showed that GLUT1 could serve as a predictor of poor prognosis. We further predicted and screened the candidate non-coding RNAs (ncRNAs) upstream of the GLUT1 mRNA through correlation analysis, and found that the CASC19/miR-140-5p axis contributing to the regulation of GLUT1 expression. Our study suggested a link exists between GLUT1 expression and selected immunity-related indicators. Subsequent analysis revealed overexpression of GLUT1 in pancreatic cancer specimens and patients with highly expressed GLUT1 expression had worse prognosis. Based on the significantly different expression of GLUT1, the possibility that GLUT1 participated in tumor progression was identified. Using online public databases, genes co-expressed with GLUT1 were screened and enriched to metastasis-related pathways by enrichment analysis. Additionally, functional assays verified that GLUT1 could function in the metastatic process of PAAD cancer cells. Therefore, we proposed that GLUT1 might serve as a role in tumor immunity and tumor metastasis, and was expected to be a prognostic factor in PAAD. Ivyspring International Publisher 2022-05-13 /pmc/articles/PMC9174867/ /pubmed/35711842 http://dx.doi.org/10.7150/jca.72161 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Li, Fengjiao
He, Chong
Yao, Hanming
Liang, Weiling
Ye, Xijiu
Ruan, Jianmin
Lin, Lijun
Zou, Jinmao
Zhou, Shurui
Huang, Yuzhou
Li, Yaqing
Chen, Shaojie
Huang, Kaihong
Lian, Guoda
Chen, Shangxiang
GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network
title GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network
title_full GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network
title_fullStr GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network
title_full_unstemmed GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network
title_short GLUT1 Regulates the Tumor Immune Microenvironment and Promotes Tumor Metastasis in Pancreatic Adenocarcinoma via ncRNA-mediated Network
title_sort glut1 regulates the tumor immune microenvironment and promotes tumor metastasis in pancreatic adenocarcinoma via ncrna-mediated network
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174867/
https://www.ncbi.nlm.nih.gov/pubmed/35711842
http://dx.doi.org/10.7150/jca.72161
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