Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells

The N‐terminus domain (NTD) of the SARS‐CoV‐2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical‐stage multi‐kinase inhibitor, potently inhibits Omicro...

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Autores principales: Chan, Marina, Holland, Eric C, Gujral, Taranjit S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174875/
https://www.ncbi.nlm.nih.gov/pubmed/35579119
http://dx.doi.org/10.15252/emmm.202215919
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author Chan, Marina
Holland, Eric C
Gujral, Taranjit S
author_facet Chan, Marina
Holland, Eric C
Gujral, Taranjit S
author_sort Chan, Marina
collection PubMed
description The N‐terminus domain (NTD) of the SARS‐CoV‐2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical‐stage multi‐kinase inhibitor, potently inhibits Omicron NTD‐mediated cytokine release.[Image: see text]
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spelling pubmed-91748752022-06-13 Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells Chan, Marina Holland, Eric C Gujral, Taranjit S EMBO Mol Med Correspondence The N‐terminus domain (NTD) of the SARS‐CoV‐2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical‐stage multi‐kinase inhibitor, potently inhibits Omicron NTD‐mediated cytokine release.[Image: see text] John Wiley and Sons Inc. 2022-05-17 /pmc/articles/PMC9174875/ /pubmed/35579119 http://dx.doi.org/10.15252/emmm.202215919 Text en © 2022 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Correspondence
Chan, Marina
Holland, Eric C
Gujral, Taranjit S
Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
title Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
title_full Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
title_fullStr Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
title_full_unstemmed Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
title_short Olverembatinib inhibits SARS‐CoV‐2‐Omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
title_sort olverembatinib inhibits sars‐cov‐2‐omicron variant‐mediated cytokine release in human peripheral blood mononuclear cells
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174875/
https://www.ncbi.nlm.nih.gov/pubmed/35579119
http://dx.doi.org/10.15252/emmm.202215919
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